Tag Archives: essential amino acids

Eating Turkey Makes You Sleepy: True or False?

https://www.youtube.com/watch?v=aa1_CeUAQIc#action=share

Many of us have probably heard or even experienced the famous phenomenon known as food coma. If you have no idea what food coma is, you most probably have experienced it before unknowingly. Food coma is a state of lethargy or sleepiness experienced after consuming a large portion of food. Despite its informal name, it is a medically recognized condition called post-prandial comnolence.

Food coma generally hits harder at the most festive times of the year- the holiday seasons. The thanksgiving turkey is no exception. You stack your plates with turkey, sweet potatoes, dressing, cranberries and all the other old-fashioned foods, then fill your stomach up to the brim. Then, of course, you go for a second, then third round. It’s the holiday seasons after all. Not long after, you start to feel lethargic, energy-less and sleepy. Unknowingly, you have fallen into the food-coma trap.

For many years, urban myths have blamed the turkey for the main cause of the sleepiness. But is the turkey really to be blamed?

Where did the myth come from?  Many of you might have heard about the amino acid called tryptophan. Tryptophan is one of the components of the hormone serotonin. Serotonin is converted to the sleep-inducing hormone melatonin. Without melatonin, we will all be always wide awake. This chemical is essential in our body to give us enough rest at night for proper bodily functions. Hence, yes, tryptophan is an essential chemical in our body. However, our body does not produce tryptophan. Tryptophan is obtained by our body from the food we eat.

The tryptophan we ingest competes with other amino acids in our body to enter our brain through the blood-brain barrier. The blood-brain barrier is an interface that separates the brain from the rest of the body. It protects the brain from harmful chemicals that enters the body by filtering them. The blood-brain barrier will only allow certain chemicals to enter the brain. Only a portion of the tryptophan we ingest successfully enters our brain. Most of them are broken down in our liver. The myth that turkeys make us sleepy began when tryptophan were found in turkey meat.

So, do turkeys make us sleepy? The answer to this question is- yes and no. Turkey meat contains tryptophan-yes. However, according to Standford neuroimmunologist Lawrence Steinman, MD, the levels of tryptophan  in turkey “is not higher than in most other muscle tissue from other animals, more commonly known as meats”. It is not the turkey that makes us sleepy but it is the enormous amounts of carbohydrates and often alcohol consumed on the holiday seasons.

Carbohydrates such as the dressing or mashed potatoes induces the release of insulin into the bloodstream compared to other amino acids present. As a result, higher levels of tryptophan are concentrated at the brain-blood barrier.

In conclusion, it is not the turkey that makes you sleepy after Thanksgiving. So, take a quick nap on Thanksgiving, but be sure to wake up in time for the dishes!

There is Hope: Body Fat Transplant May Be Effective in Treating Rare Metabolic Diseases?

People who have rare metabolic diseases, such as Maple syrup urine disease depend highly on donor transplantation. But is there an alternative treatment if donors are low? Not to mention the high expenses of a transplant?

But… you might be wondering… what exactly is maple syrup urine disease and where does it get its name?

Maple syrup urine disease (MSUD) is a rare disease because it follows an autosomal recessive mode of inheritance, one of the ways a disease can be passed down through families. This means patients inherit MSUD if both their parents have an abnormal gene.  MSUD  causes a defect in the way our body breaks down the three essential amino acids: leucine, isoleucine, and valine.

Maple syrup urine disease (MSUD) follows a autosomal recessive mode of inheritance. Source: Wikipedia Commons

Maple syrup urine disease (MSUD) follows a autosomal recessive mode of inheritance. Source: Wikipedia Commons

It is characterized by the distinctive maple-syrup scent found early on in urine samples of infants. They are important because essential amino acids cannot be made from the body, so they must come directly from our diet. The defect causes these three amino acids and their by-products to build up in the body. As a result, MSUD patients need precisely monitored diets (measured to the very milligram!) to avoid consumption of these amino acids, while still obtaining the other essential amino acids the body needs.

If MSUD conditions are left untreated, they can lead to coma, seizures and even death before reaching three months in age.

Liver transplantation is shown to be effective in treating MSUD because the liver is composed of an abundance of enzymes which appear to normalize amino acid levels, sometimes even allowing patients to fully adopt their normal diets again.

So organ transplantation is usually the solution to metabolic diseases but because of the high demand, is there a more accessible alternative?

Noting the high activity of fat tissue relative to muscle tissue in the body, researchers from Penn State College of Medicine tested the effect of body fat transplantation with genetically engineered mice with MSUD. They transplanted two grams of fat into the mices’ back or abdomen and found that when they implanted fat into the mices’ back, the amino acid levels dropped greatly in the transplanted MSUD mice compared to non-transplanted MSUD mice.

Transplanting fat into the abdomen of the mice did more harm than good and caused inflammation in the process. The results of this study were recently published in the journal Molecular Genetics and Metabolism.

Their study concluded that the amount of fat injected had no effect on the results. So this must mean that there will be further experimentation with fat transplantation. Fat transplant can be an alternative to liver transplant because it may be a more efficient approach as it is relatively inexpensive and it may be easier to find donors.

Wayne and Chad’s personal account on their child living with MSUD: YouTube Preview Image
Posted on January 25, 2016 By Jenny U

The Vegan Movement: Should we really stop eating red meat?

Veganism is growing rapidly amongst the current generation, whether perpetuated by scientific reasoning or simply through social media. Do we truly know what to believe anymore or which diets are the best for us? One popular belief that has upset many meat-lovers is that the consumption of red meat increases the risk of cardiovascular disease (CVD). The main reason is the reaction between a component of the red meat and natural bacteria found in our stomachs.

Steak; everyone’s favourite red meat! Source: Google Images

L-carnitine is an amino acid found naturally in the human body and is also abundant in all the delicious red meats that we eat such as lamb, beef and pork. On its own, L-carnitine helps the body produce energy by facilitating heart and brain functions, as well as muscle movement. However, this study shows that when the digested amino acid is broken down by the natural bacteria in our stomachs, a harmful chemical compound called trimethylamine N-oxide (TMAO) is produced.

TMAO found in blood was shown to result in atherosclerosis, more commonly known as ‘clogged arteries’. Immune cells that exist in the arteries build up cholesterol more significantly in the presence of TMAO. In addition, the study showed that arteries that were exposed to more L-carnitine became more efficient at producing TMAO. Based on their experiments, vegans and vegetarians who were less exposed to the amino acid were shown to convert at a much slower pace.

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So what does this mean for all the meat-eaters? Is this enough evidence to prove that we should completely stop indulging in these sinful dishes? Perhaps turn vegan? An underlying issue is how frequently we consume red meat. Studies have enough support to show that people who eat more red meat have higher risks of CVD, however, the actual amount of consumption to warrant these consequences is still unclear. Just like with any other unhealthy foods, finding a balanced diet will help you avoid problems. Moderation is key!

  • Siriwat Chhem, January 18th 2016