Tag Archives: science

Polymers with the Ability to Glow

Science has many applications to our everyday lives which go unseen. From the moment the alarm clock wakes you up, to the moment you turn off the lights to go to bed, science is directly impacting your life.

You may be surprised to find out that a chemistry study in its early stages may have great implications for the situations you experience on a daily basis.

Benjamin Rawe, a chemist  at the University of British Columbia, has been studying polymers that have phosphorus in their backbone. This study produced a polymer which can glow!

But what are polymers? In essence, polymers are repeating units made of monomers, which are individual molecules. Using these polymers, Dr. Rawe added phosphorus to the them. Phosphorus is an element with very interesting properties because it can react with many things. When this element is incorporated into the polymer backbone it fluoresces, which means that it can glow. It is easy to think of  the phosphorus like a switch for the polymer. So based on what is attached to the phosphorus, you’re either turning on or turning off the fluorescence.

The video below explains in detail what polymers are and the properties of phosphorus that make it essential to this study.

Credit: Daniela Castillo & Vanessa Sidhu

The real-life application for these polymers that contain phosphorus is the possible ability for them to be used as sensors. Sensors are objects that detect an event or change, and respond to that change. Sensors are required for many parts of our daily lives, they are used in thermometers to measure your fever, the light that turns on when you walk by, and even the metal detector used at airports. Furthermore, the Global Positioning System (GPS) and smartphones are technologies that are on the uprise. The potential application for more efficient sensors in these items could help enhance these technologies even more.

The podcast below gives examples of sensors and their importance in our growing population.

Credit: Kush Khanna & Siriwat Chhem

The research on this topic is just getting started, there is much more to study and discover. Benjamin continues to learn more about the polymer he has created and the significance it can have in our society.

– Vanessa Sidhu, Daniela Castillo, Kush Khanna and Siriwat Chhem

Poisonous Potatoes? Your Spuds Can Kill You!

Potatoes are a staple food in North America and many other places of the world, but did you know this spuddy delight could possibly kill you? In 1978, a large group of boys in a school suffered from severe diarrhea and vomiting. 17 of them even required to be hospitalized and the 3 most severely affected children were even comatose. The cause? Eating a significant amount of toxic potatoes.

But how could potatoes, something the entire world eats nearly everyday cause such a ruckus? Well, potatoes as we consume them are generally not toxic. However, old potatoes that have started turning green start to produce a toxin called Solanine. Generally, people feel that it is a waste to throw away food and may possibly eat a potato that has slightly turned green, but eating too many of these could possibly destroy your digestive system!

A study evaluating the toxicity of solanine found that when rabbits were administered solanine, they encountered breathing difficulties and partial paralysis of limbs. Some were eventually found to be dead.  The results of this study highlight how important it is to be mindful of any leftover potatoes that have started turning green or even started budding; it is safer to throw these away rather than risk your personal health just to save a few dollars.

It is very important that more people be informed about this because almost every household in North America consumes potatoes and young children, who are more susceptible to lower doses of toxins are at risk here. Unknowing parents could possibly cook up some greening spuds which, at lower doses may not affect them but could possibly cause their children to fall severely ill. 

So, the next time you find a potato that has been left for too long, despite how hungry or strapped for cash you are, please remember that you risk paying a much higher price for eating it than you would throwing it away. However, why should I pick on the potato only? Below is a video showing other commonly consumed items that pose just as much, if not more of a risk than the potato.

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Energy Drinks And Health Effects

The consumption of energy drink is common in all age groups and is significantly increasing. Energy drinks are almost available in all countries in different brands. It is assumed by most people that drinking it, is safe and guarantees its purpose which is giving energy but the health effects are mostly forgotten.  The health effects can range from mild to severe or even dead. Even with all the health issues, the energy drink market will increase to about $21 billion in annual sales by the end of 2017.

The health effects of energy drinks are cardiac arrest, headaches, type 2 diabetes, vomiting, high blood pressure, increased anxiety, insomnia, risk behaviour and nervousness. It has been reported in the United States that due to energy drinks there have been 18 deaths, 150 serious injuries and the number of hospital beds doubled, from 2004 to 2012. The health issues of energy drinks are clear but still the consumption of it, keeps increasing and reasons might be that people either ignore the facts or they need to be educated. In the United States, the consumption of energy drinks have always been on a rise and it is expected that from 2014 to 2019 it will increase up to 52%, which is an enormous amount.  

Energy drink volumes

Image source: Market Realist

Internationally, energy drink market has raised by 15% and will continue to increase. Surprisingly, the largest consumer is Latin America and interesting North America is the second lowest.

Energy Drinks Shows Impressive Stamina

The customers of energy drinks are almost everyone ranging from teenagers, adults and maybe even kids. Also, it is consumed by male and female. It is found that 66% of energy drink consumption are by people ages 13 to 35. But it is considered that males consume it more than females. In a study by Nowak and Jasionowski, they had 1481 female and 1148 male participants from which they concluded that males usage of energy drinks are higher than females. It was found that 60.8% females and 74.5% males, consumed energy drinks. An interesting fact found in the study was that about 21% of teenagers took energy drink for no specific reason whereas it is mostly taken for the reasons of tiredness, physical activity or caffeine consumption. 

One sad story related to energy drinks was in the case Lanna Hemann, a 16-year old who died from consuming the drink while being on vacation without her parents. To make the long story short, she consumed an energy drink from which she went into cardiac arrest and passed away.

In conclusion, the consumption of energy drinks is related to many health issues which may result in even death. With the increase in energy drink market, it possesses a risk to everyone but especially young people because they might not be aware of the health effects. Therefore, avoiding energy drinks completely is the best way to live a healthier life.

 

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source: National Science Teachers Association

March 14th, 2016

Hamed Hussaini

The Epigenetic Relationship Between Income and Aging

You are probably familiar with the old nature versus nurture debate if you have ever taken a course in psychology or philosophy. It inquires whether our development is induced by our DNA, individual choices we make or by our environment and circumstance. Twins are often used to demonstrate the effects environmental factors have on phenotype.

In the early 1990’s a scientist by the name of Conrad Waddington found that environmental stress was causing certain phenotypes of the Drosophila fruit fly to assimilate. In other words, these phenotypes that were first induced by the environment were becoming permanent and hereditary! Waddington named this area of research Epigenetics; a now growing field of research that looks at how environmental factors can change our phenotype.

Dr. Courtney Griffin, a member of the Cardiovascular Biology Research Program at Oklahoma Medical Research Foundation discusses the importance of Epigenetics in this TedX video.

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Many studies in recent years have attempted to reveal a connection between low income and risk for diseases such as heart disease and cancer. What all of these studies have looked at is telomere degradation. As cells divide, the length of these chromosome-caps contracts implying aging. As an indicator of aging, telomere degradation remains unreliable and results from these studies have proven inconsistent.

A new study by Ronald Simons et al. has demonstrated a correlation between accelerated aging and income by a new method. The researchers were able to identify certain epigenetic markers that can be linked to aging by way of DNA methylation. This process involves adding methyl groups to DNA. As the methylation level of a gene increases, the expression of the gene decreases (Read more about DNA methylation here).

A sample of 100 middle-aged, American black women were chosen for the study as the population of black men in America had high incarceration rates (forcing the financial burden on the mother of a family) and low family incomes. The study controlled for other influences of socio-economic status (SES)  such as education, and used a new method of structural equation modeling to find that low income was associated with biological aging.

Income inequality is one of the largest problems the United States faces today as 99% of new income is being distributed to merely one percent of the population. This study implies that this problem may be even worse than previously understood. If these biological effects are in fact hereditary, the vast population of low-income wage earners in America can expect their children and grand children to live shorter lives.

-Johnny Lazazzera

Organisms Inside Us

Have you ever wondered how many micro organisms are living inside us? Micro organisms are living organisms that cannot be seen with our naked eyes. They may be multicellular (made out of more than one cell) or unicellular (made out of one cell). Our human body is packed with trillions of microbes (or micro organisms). In fact, our own body cells are out numbered with a ratio of 1:10. So, we are technically 90% germs and 10% human. Microbes are found in all parts of our body in different proportions. Our lung has approximately 1000x less microbes than our mouth and has approximately 1 billion times less microbes than our intestines. Although most microbes are harmless to us, some may cause bacterial infections in humans.

The Human Body = 90% Germs + 10% Human

Top three functions microbes in our body:

  1. Defense mechanism: Microbes in our lungs, intestines and our skin provide the first line of defense against harmful bacteria that enters our body. Good microbes found in these areas play an essential role in preventing the spread of harmful microbes by occupying space so less space are available for harmful microbes to settle down inside us. Thus, preventing us from bacterial infections that may cause fever, diarrhea or other problems. Other than that, researchers have found evidence that microbes that live inside us help promote our immune system cells to grow and replicate.
  2. Keeping us in shape: The trillions of microbe colonies in our intestines help digest fats and carbohydrates, facilitating the absorption of nutrients in cells. Our intestinal microbes also ferment food that we consume. The fermentation process produces chemicals that speeds up our metabolic processes. As a result, the microbes in our gut helps us keep in shape by increasing our metabolism.
  3. Detoxifies us: Microbes living in us are also capable of digesting toxins that we accidently ingest into less harmful substances. Therefore, preventing us from being poisoned. For example, the microbe Lacrobacillus probiotics found in food help the human body detoxify heavy toxic metals such as aluminum.

Good microbes that keep us healthy

Where do we get microbes that live in our body? Most of our microbes that inhabit our intestines comes from the food we ingest. Our skin and lung microbes come from the air we are exposed to. Recently, researchers discovered that newborn infants get their microbes from their mother’s breast milk and vagina. Researchers found that the method of delivery may have an effect on the diversity of intestinal microbes in newborns. They discovered that infants born vaginally and infants born by caesarean section have different intestinal microbe composition. This indicates that we start to develop our microbe colonies from the day we were born.

Microbes inside our body

From Sugar to Morphine

Morphine is an opiate (derived from opium) painkiller, one commonly prescribed for chronic (long-term) and acute (short-term) pain. The current process for making morphine is very extensive and requires farming opium poppies for their poppy straws, from which the morphine is isolated. Morphine is on the Model List of Essential Medicines, formed by the World Health Organization (WHO), which comprise the most important medications for a basic health-care system. Morphine is also used to make other opioids such as oxycodone and methadone.

Image of the opium poppy. Via Wikimedia Commons

Image of the opium poppy. Via Wikimedia Commons

Escherichia coli (E. coli) is a bacterium commonly known for causing food poisoning. Although some E. coli are beneficial and live in our gut, there are many that can cause infections. As the energy-producing processes of these bacteria were similar to the processes involved in making opiates such as morphine, a team of researchers wondered if they could use E. coli to convert sugar into painkillers.

The study, which was published in Nature Communications, was centered around using E. coli to create a precursor to morphine known as thebaine. A precursor is a substance that is used to produce the next substance; thus, thebaine is used to produce morphine. The researchers accomplished this by using four engineered strains of E. coli.

Image of E. coli. Via Wikimedia Commons.

Image of E. coli. Via Wikimedia Commons.

This research has significant implications because of the time it currently takes to produce painkillers. Many poor countries have limited access to opioids, or no access at all. Other production techniques, such as using genetically engineered yeast to produce painkillers, are not efficient enough to challenge tradition opium poppy farming. By using E. coli, the researchers were able to produce 300 times more of the opioid precursor. Another benefit in using bacteria for the production of opioids is that it would only require simple sugars, such as glucose. The yeast production method also faced ethical issues, as anyone that had access to the yeast strain could produce the opioids, leading to the production of street drugs. The E. coli method does not face this problem as the bacteria are difficult to manage and require expert handling.

Image showing heroin, a common street drug. Via Wikimedia Commons.

Image showing heroin, a common street drug. Via Wikimedia Commons.

Once the technique has improved further to increase its efficiency and passed all pharmaceutical regulations, the manufacturing of opioids from bacteria could help solve the deficit in painkillers that the world faces.

Kush Khanna

Will Human Head Transplant Work?

Science has advanced very much in the field of medicine with discoveries that give people another chance to live. In the past century, there have been many new inventions including new medicines, vaccinations and organ transplant in humans. However, the idea of a head transplant was only a mystery which was only seen in movies such as Frankenstein. Surprisingly, that fiction is about to become a reality in the near future. In the next year or two, Italian neurosurgeon Sergio Canavero is to perform the first ever human head transplant which will evolve science to new echelons.  According to Canavero, the surgery is intended for those who have a fully functioning head, but endure a paralyzed body from the neck down due to some type of incurable disease or injuries suffered from accidents. The healthy head will be placed onto a healthy body of someone who is brain dead, and there is “90 percent” chance for the surgery to succeed.  Similar to other complications, “of course there is a marginal risk” according to Sergio Canavero.

The surgery of head transplant never performed before, and with the risks being higher than any other normal standard operation, Valery Spiridonov, a Russian computer scientist is willing to be the first patient. Spiridonov suffers from a motor neuron disease called Werdnig-Hoffmann Diseasewhich leads to the shrinking of the muscles every day and can cause difficulties breathing and swallowing. Currently, there is no cure for the disease and the head transplant can be a potential cure in the near future. Head transplant can also be a cure for those suffering from spinal cord injuries due to accidents, such as car crushes, falling from heights and others. 

valery spiridonov

Valery Spiridonov, first to be patient of head transplant

Photo Credit: Huffingtonpost, UK

The estimated time for the operation is about 36 – 72 hours, with about 80 surgeons involved, and the estimated cost to be about 11 million British Pounds which is $15 – 16 million US dollars.  The procedure of the operation will involve, first cutting the head of the patient with a really sharp blade, then using special surgical glue called polyethylene glycol, to attach the head into the new body and then stitching up the blood supplies. Afterwards, the patient will be put into coma for about four weeks to allow the head to heal with the new body, and small electric shocks given in order to improve the flow of connection. After the patient wakes up, everything is expected to be normal such as the functioning of the senses and movement coordinations. If this operation succeeds, more people could experience a second chance at survival and a new life. For a detailed procedure, please read this.

Blood vessel connection

Photo credit: The Telepgraph, UK

In conclusion, I think head transplant operation is another step towards expanding science and with its success, it can give lots of people hope and perhaps a new life to look forward too.

For detailed information watch:

https://www.youtube.com/watch?v=FmGm_VVklvo

Video credit: Juanker52

  • Hamed Hussaini, January 25th 2016