Category Archives: Outreach Project

The Link Between Calcium Channel Insertion and Changing Secretion

Do you or someone you know suffer from diabetes? If so, you may know that this disease is a result of decreased insulin secretion from the pancreas. Decreased secretion of hormones like insulin may have detrimental effects on an individual. For this reason, researchers have conducted experiments in an attempt to understand how secretion works.

Dr. Christopher Groten, who is currently conducting research at the University of British Columbia, has found that the insertion of new additional calcium channels (Cav2) into the membrane of cells increases secretion of hormones. Specific to Dr. Groten’s research, the model organism Aplysia californica secretes a hormone called egg-laying hormone (ELH). This hormone is released upon activation of a particular enzyme called PKC.

https://youtu.be/SATOrk6w7-M

Credit: Brian Infanti

Often the transportation of calcium across the membrane occurs in response to a stimulation. However, the process involved is not well understood. Therefore, observing an organism with a simpler nervous system, such as Aplysia californica, allows researchers to better understand this mechanism by which calcium enters the cell. Correspondingly, Dr. Groten uses A. californica in his research because he believes that “Aplysia is a good organism to study because the behaviour is really well known, and it has a reduced nervous system”. Essentially, calcium channels are important for carrying out many vital processes in our body. Below, you’ll find a clip that might help answer a few questions about calcium channels in general.

https://soundcloud.com/brian-infanti/so-group-6-podcast

Credit: Brian Infanti

According to the podcast, there are many diseases associated with calcium channel deficiencies. Another study shows how specific areas of cells are associated with increased calcium channels and increased secretory vesicles. As a result, this leads to greater release of hormones. Perhaps a connection between calcium channel insertion and regions with lots of secretory vesicles can be made by relating this particular study to Dr. Groten’s findings in order to lead to other therapeutic strategies for various diseases.

As world population increases and diseases such as diabetes become more prevalent, further resources are required to improve research. For instance, Public Health Agency of Canada reported spending $15 million in the past 4 years on funding for the National Population Health Study of Neurological Conditions. With this type of funding in the public health sector, research like Dr. Groten’s can help lead to new discoveries that benefit the public.

– Paria Assadipour, Daniel Kim, Brian Infanti

Understanding Absence Epilepsy

Did you know that epilepsy is the fourth
most common neurological problem of our society?

Epileptic seizures are the result of abnormal activity in the brain. Source: Youtube

Epileptic seizures are the result of abnormal activity in the brain. Absence epilepsy is one form of epileptic seizures, characterized by a momentary loss of awareness, usually lasting less than ten seconds. What differs an epileptic seizure from a non-epileptic seizure is that it is recurrent and non-epileptic seizures may be induced by psychological issues or stress-related factors.

Absence epilepsy is often associaed with children who have trouble in school, social problems, or who misbehave often. Source: Flickr

Absence epilepsy is often associated with children who have trouble in school, social problems, or who misbehave often. Source: Flickr

This condition is more common among children than in adults. As a result, absence seizures are often mistaken as daydreaming or periods of blanking out. Symptoms of absence seizures include fluttering eyelids, smacking of the lips, or rubbing fingers together. Absence epilepsy is often associated with children who have trouble in school, social problems, or who misbehave often. Most children will outgrow their seizures by age 18, however in some cases they can continue throughout the rest of their lives.

To understand a bit more about absence epilepsy, the podcast below depicts a scenario of a child experiencing absence seizures and how current research will fuel further medical studies to help with this disorder.
YouTube Preview Image

There are current studies being conducted on the causes of this condition at the University of British Columbia, and we interviewed Dr. Stuart Cain at the Djavad Mowafaghian Centre for Brain Health about his research on absence epilepsy.

The main focus of Dr. Cain’s research is on calcium channels in the brain, and the role they play in absence epilepsy. It is found that the overactivity of certain calcium channels located specifically in the cells of the brain leads to a phenomenon known as “burst-firing”, and this is thought to be what triggers absence seizures.

The causes of absence epilepsy are still unknown, although there are many theories as to what causes an absence seizure. Dr. Cain believes that when overactive brain cells in one specific region communicates with two other regions of the brain and causes them to be stuck in a synchronous loop; this is what causes absence epilepsy.

The video below explains further on how absence seizures occur, and what the main findings of Dr. Cain’s research were:
YouTube Preview Image

There are currently two types of drugs available to treat absence epilepsy, and although they work for most people in stopping absence seizures from occurring, they have not been shown to be 100% effective.

Dr. Cain and his team of researchers’ study serve as foundation for further development of anti-seizure medications to control absence seizures. He believes that in order to find a drug that will be completely effective in controlling absence seizures, the drug will need to target the calcium channels in the brain which cause burst-firing. Dr. Cain suggests that the next move is to push pharmaceutical industries to create a drug capable of doing just that. If this proves to be successful, perhaps then children will not have to worry about absence epilepsy affecting their lives.

Posted on April 4, 2016
By Emma Peachey, Jenny Ung, Karanvir Gill, Harsh Bhatt