Author Archives: paria

The Link Between Calcium Channel Insertion and Changing Secretion

Do you or someone you know suffer from diabetes? If so, you may know that this disease is a result of decreased insulin secretion from the pancreas. Decreased secretion of hormones like insulin may have detrimental effects on an individual. For this reason, researchers have conducted experiments in an attempt to understand how secretion works.

Dr. Christopher Groten, who is currently conducting research at the University of British Columbia, has found that the insertion of new additional calcium channels (Cav2) into the membrane of cells increases secretion of hormones. Specific to Dr. Groten’s research, the model organism Aplysia californica secretes a hormone called egg-laying hormone (ELH). This hormone is released upon activation of a particular enzyme called PKC.

https://youtu.be/SATOrk6w7-M

Credit: Brian Infanti

Often the transportation of calcium across the membrane occurs in response to a stimulation. However, the process involved is not well understood. Therefore, observing an organism with a simpler nervous system, such as Aplysia californica, allows researchers to better understand this mechanism by which calcium enters the cell. Correspondingly, Dr. Groten uses A. californica in his research because he believes that “Aplysia is a good organism to study because the behaviour is really well known, and it has a reduced nervous system”. Essentially, calcium channels are important for carrying out many vital processes in our body. Below, you’ll find a clip that might help answer a few questions about calcium channels in general.

https://soundcloud.com/brian-infanti/so-group-6-podcast

Credit: Brian Infanti

According to the podcast, there are many diseases associated with calcium channel deficiencies. Another study shows how specific areas of cells are associated with increased calcium channels and increased secretory vesicles. As a result, this leads to greater release of hormones. Perhaps a connection between calcium channel insertion and regions with lots of secretory vesicles can be made by relating this particular study to Dr. Groten’s findings in order to lead to other therapeutic strategies for various diseases.

As world population increases and diseases such as diabetes become more prevalent, further resources are required to improve research. For instance, Public Health Agency of Canada reported spending $15 million in the past 4 years on funding for the National Population Health Study of Neurological Conditions. With this type of funding in the public health sector, research like Dr. Groten’s can help lead to new discoveries that benefit the public.

– Paria Assadipour, Daniel Kim, Brian Infanti

Intimately Entangled – A Quantum Mechanical Love Story

 

Albert Einstein 1879-1955. Wikimedia Commons

Albert Einstein 1879-1955.
Wikimedia Commons

The man of the hour, Albert Einstein, has made quite an impact throughout the history of theoretical physics. Most recently however, the gravitational waves that Einstein’s theory of relativity predicted were detected on September 14, 2015 at 5:51 a.m.

An intelligent man indeed, yet even the brightest minds can be wrong. For instance, this brilliant theoretical physicist was unable to wrap his mind around an idea that arose from the theory of quantum mechanics – quantum entanglement.

'Intimately entangled' giraffes. Pinterest

‘Intimately entangled’ giraffes.
Pinterest

Quantum entanglement is a phenomenon that allows us to know the state of one particle if we measure the state of it’s partner particle. In essence, these two particles remain intimately ‘entangled’. Einstein remained unsatisfied about the notion that these particles were able to determine each others’ fate even at large distances apart. He argued that this “spooky action at a distance” should not be considered a theory as it holds too much uncertainty.

Due to Einstein’s apprehension towards quantum entanglement, John Stewart Bell came up with Bell’s inequality experiments. Bell’s tests showed a correlation between entangled particles which were a distance apart and this correlation was observed “more than a percentage of the time”.

However, 3 loopholes in Bell’s experiment were discovered and could have eradicated the idea of quantum entanglement had they not been closed by today’s scientists. The first loophole points out that all entangled particles are not detected, meaning that the undetected photons could potentially change the statistical results that support quantum entanglement. The second loophole marks the notion that the entangled particles may affect each other’s state before detection by observers. The final loophole states that this idea may not be random at all, and that the observer is actually unable to detect the pattern.

The first two loopholes were closed by Hanson and his team; their experiment used diamonds to observe the state of all the photons which closed the first loophole, as for the closure of the second loophole, the electrons emitting the photons in their experiment were far enough apart that they were not able to communicate before the observer detected their states. A solution to the final loophole is currently in the works attempting to explore the random nature of the detection of photons. A paper submitted by Dr. Lynden Shalm and his team, that has yet to be peer-reviewed, has shown their attempt at using “random number generators and high-speed polarization measurements” to prove the random behavior of the particles.

The following video by Joe Scott found on YouTube indicates how scientists are currently closing loopholes.

Sorry Einstein, but it seems that quantum entanglement is looking pretty feasible thanks to the work done by scientists. They’ve worked on closing Bell’s loopholes and thus provided support for quantum entanglement.

Working with this theory of quantum entanglement, society can look forward to research into more efficient computing. For instance, in 2013 Google and NASA experimented with a computer that runs 108 times faster than a typical PC, and this is just the beginning.

 

                      – Paria Assadipour

To drink, or not to drink…

Paracelsus

Paracelsus Source: Wikimedia Commons

Society has always incurred the issue of dosage. To quote the famous philosopher, Paracelsus, “All substances are poisons; there is none that is not a poison. The right dose differentiates a poison and a remedy.”

Parcelsus’ words do not falter, especially with regards to alcohol consumption. Particularly in red wine, there is a “substance” called resveratrol, a naturally occurring chemical compound found in the skin of certain grapes and berries considered to be an antioxidant. A blog from cancer research UK indicates that a low dose of resveratrol is considered to be 5 milligrams which is equivalent to a 250 mL glass of wine, or roughly 9 ounces. This minimal dose would be enough resveratrol to have an observable effect on the human body.

But how does resveratrol affect the body? You may have heard about the relation between red wine and the heart. In fact, the video below by Buzz60 introduces a study conducted in Israel by the Ben-Gurion University of the Negev which has shown that red wine has an increased positive effect on cholesterol levels. The study had 1/3 of the subjects drinking a glass of water with their meal, 1/3 drinking white wine and 1/3 drinking red wine. Excuse the cheese of this video, but it does go quite well with these wine facts.

http://www.dailymotion.com/video/x3aobr3

As mentioned, resveratrol is an antioxidant; it donates an electron to the free radicals in the body, thereby abolishing the harmful abundance of radicals. By inhibiting free radicals, resveratrol promotes the production of nitric oxide. Consequently, the presence of this biological messenger – nitric oxide – stimulates arteries to relax, open up and allow blood to consistently flow throughout the body. This constant flow aids in the avoidance of a coronary artery spasm; a condition defined as the temporary yet sudden narrowing of the artery walls.

Essentially, red wine contains resveratrol, resveratrol promotes the production of nitric oxide and nitric oxide allows blood vessels to dilate allowing blood to flow steadily throughout the body. The video below echoes this process.

https://www.youtube.com/watch?v=eVoH67d0IDk

So, to sum it all up, go ahead and get that 9 oz of red with your dinner! Your circulatory system prefers it.

Paria Assadipour