Exercise- A New Way to Prevent Alzheimer’s Disease.

As the global population is aging, the number of elderly suffering from Alzheimer’s disease or dementia are predicted to increase to an estimated 75.6 million in 2030 and 135.5 million in 2050. Every 67 seconds, someone in the United States develops Alzheimer’s disease. Today, it is ranked the sixth leading cause of deaths in America. Although a growing number of researchers are studying the disease, Alzheimer’s disease is still the only cause of death in the top 10 that cannot be prevented, cured or slowed.

Alzheimer’s Disease Facts. Source: Alzheimer’s Association

A recently published study in the Journal of Alzheimer’s Disease showed that calories-burning activities are linked with greater gray matter volume in brain areas responsible for cognition and memory. Gray matter in the brain consists of most of the brain’s neurons responsible for muscle control, emotions, speech and memory. Patients suffering from Alzheimer’s disease or dementia have decreasing gray matter volume in the brain, thus affecting their cognition and memory. Halting the reduction in gray matter volume might be the effective way in preventing dementia and Alzheimer’s disease.

Normal brain vs. Alzheimer’s brain. Source: Bioinformatics

The study conducted by scientists at UCLA and the University of Pittsburgh School of Medicine revealed that participants who suffer from Alzheimer’s disease or dementia who are physically more active experience less reduction in gray matter volume than those who are physically inactive. Participants who are physically active also experience less cognitive and memory declines.

Researchers gathered five years of data from 876 participants aged 65 and older. Brain scans, cognitive tests and interviews were conducted to gather accurate data about their cognitive health, physical health and physical activities over the period of five years. Participants filled questionnaires to evaluate their leisure time, physical activities and cognitive abilities.

Scientists revealed that those who exercise the most have a 5% larger gray matter volume than those who exercise the least. 5% decrease in gray matter volume corresponds to 50% lost in cognitive and memory functions. The brain scans revealed that participants who exercised the most have denser gray matter in the frontal, temporal and parietal lobes, which are the areas responsible for learning, cognitive tasks and memory.

Frontal, parietal and temporal lobes of the brain and their functions. Source: My Brain Tests

Scientists are encouraging doctors to start dementia and Alzheimer’s disease prevention by encouraging regular physical exercise instead of waiting for memory loss to start. Past studies have shown that delaying the development of Alzheimer’s disease by ten years would eliminate the disease as the elderly would die of other causes first before developing the disease.

Even though scientists have no fixed number of how much exercise it takes to prevent dementia, researchers estimated that the people need about an extra 500 calories per day to be burnt. Luckily, it doesn’t matter how the extra calories are burnt, as long as they are burnt.

Experimental Dengue Virus Vaccine found to be 100 Percent Effective

As many of us know, the dengue virus has affected billions of people since the early 19th century. The dengue virus is transmitted by mosquitos and is known to cause dengue fever. It is similar to other well-known viruses, such as the West Nile Virus, or the recent Zika Virus. Scientists were having difficulties creating a vaccine for the virus, as it appeared in four different serotypes (different strains). Creating a vaccine for a single strain could cause complications if the individual became infected with a different strain, as they would be unprotected. Also, if the vaccinated patient became infected with a different strain, they could go into dengue hemorrhagic shock, and die. Dengue hemorrhagic shock is characterized by bleeding, and severe low blood pressure. In most places where the disease is prevalent, all four strains of the virus cycle, thus it is important to create a vaccine that protected against all types of the virus.

The Aedes mosquito, responsible for transmitting viruses such as dengue. Via Wikimedia Commons.

The Aedes mosquito, responsible for transmitting viruses such as dengue. Via Wikimedia Commons.

The vaccine was tested in a small, double-blind trial with 41 volunteers. A double-blind trial is when neither the administrators of the vaccine nor the recipients know what they are receiving. Twenty of the recipients received a placebo (a fake shot, without the vaccine), and the remaining individuals were given the experimental vaccine. All participants in the trial were infected with a mild form of the virus six months later. The twenty individuals that were given a placebo showed symptoms of the virus, such as a rash, a low white-blood-cell count (cells of the immune system, that fight off viruses and infections), and other symptoms of the disease. The individuals given the experimental vaccine did not become sick, showed no symptoms of the virus, and did not have evidence of infection in their blood. The vaccine was developed by the National Institutes of Health (NIH), and the results were posted in Science Translational Medicine. Beth Kirkpatrick, a participant in the trial and a professor of medicine at the University of Vermont, called the experimental vaccine “100 percent efficacious” in an interview.

Stained monocytes, a type of white blood cell. Via Wikimedia Commons.

Stained monocytes, a type of white blood cell. Via Wikimedia Commons.

The results were so promising that the NIH rushed the study to large-scale Phase 3 testing in Brazil, a country where the virus is prevalent. Phase 3 is the last phase of clinical trials, where the drug or vaccine is given to large groups of people to confirm its effectiveness and monitor side effects. They plan on enrolling 17,000 adults, children, and babies and finishing Phase 3 by 2018. These results also have important implications on a vaccine for the Zika virus. As Zika and dengue are similar viruses, scientists believe what they have learned from the dengue virus can be used to cut back the timeline for developing a Zika virus vaccine.

Kush Khanna

GMOs- is it as bad as people say it is?

Are GMOs bad because it is harmful to humans? Or is it bad because people say so? Many people have misconceptions about the use of GMOs in today’s society because they often get attracted to natural products rather than “artificial” or “non-natural” products.

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Many scientific studies have concluded the safety around GMOs; none of which claimed harmful to humans, animals or the environment. However, scientific consensus have not stopped activists from demanding GMO labels to food.

There are many reasons as to why GMOs are a positive solution to our food problem today. The use of GMO’s prevent damaged crops in times of drought. It also is a safe and effective alternative to pesticides which are harmful to the environment. With a growing population, GMOs help to ensure adequate food supply for people around the world especially developing nations. Plus GM technology can maintain or keep food prices lower.

An example has been the Florida oranges that were infested by deadly bacteria. If it weren’t for GMOs, the crop was very likely to be wiped out.

It is important to do your research and understand the science behind GMOs than being pulled into public opinion. It is also good to weigh the benefits and risks. GMOs have been researched and tested widely and it is a safe and effective way of posing a solution to world hunger.

 

Posted by Lorraine Yu on March 16, 2016

Is Anybody Out There..?

While it is easy to get caught up in our day-to-day activities, it’s always nice to step back and get some perspective about our place in the Universe. One question that may come up, is whether we are alone in the Universe, or if there is intelligent extraterrestrial life out there somewhere. However, despite what some people may believe, there has been no confirmed evidence of intelligent life existing outside of Earth. However, considering the vast size of the observable universe, this is actually quite surprising from a statistical viewpoint. The Milky Way alone, on the low end, is estimated to have over 100 billion stars like our sun. Furthermore, the Milky Way is just one galaxy, and there are known to be over 100 billion galaxies in the Universe. This means that there are approximately 1 billion trillion stars in the Universe, or 10,000 times as many stars in the Universe as there are grains of sand on Earth. Each one of these stars has its own planets, and data from the Kepler spacecraft has shown that on average, each star would have at least one planet in its habitable zone.

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The Milky Way above the Paranal Observatory. Source: Wikipedia Commons.

The point is, given this astoundingly large amount of stars and their associated planets in the Universe, even if the chances of intelligent life evolving were incredibly low, given the age of the Universe, we would expect there to be billions of examples of intelligent life. However, if intelligent life is so common, we should have seen at least some piece of evidence of its existence by now. Yet, astronomers, and efforts such as the search for extraterrestrial intelligence (SETI) have yet to detect any evidence of intelligent life.

NASA-HS201427a-HubbleUltraDeepField2014-20140603

The Hubble Ultra-Deep Field. Each shape is a distinct galaxy. Source: Wikipedia Commons.

This apparent disconnect between the high probability of intelligent life, and the utter lack of evidence for its existence is known as Fermi’s Paradox. There are a number of different proposed solutions to Fermi’s Paradox that argue for, or against, the existence of intelligent life. One of the most widely accepted explanations would be the existence of some sort of Great Filter, that makes the emergence of advanced civilizations exceedingly rare. While this filter may already be behind humanity, we may also have yet to face it. Human triggered activities such as climate change or the possibility of nuclear war, show that humanity may not survive to be a species that ever leaves our Solar System. While this may seem pessimistic, humanity should realize that the Universe does not seem to be friendly to long lasting, advanced civilizations.

The fact is that at this point we only have one example of intelligent life arising, which would be ourselves. Therefore, given this sample size of one, we cannot know how common intelligent life is in the Universe is, unless we find another example of it. Whether the solution is something like the Zoo hypothesis, the Rare Earth hypothesis, or the fact that we just have not been looking for long enough, humanity should try to take better care of our own planet for now.

The YouTube video below is a great summary of Fermi’s Paradox.

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Credit: Kurzgesagt on Youtube.

By: Gulaab Sara

 

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Energy Drinks And Health Effects

The consumption of energy drink is common in all age groups and is significantly increasing. Energy drinks are almost available in all countries in different brands. It is assumed by most people that drinking it, is safe and guarantees its purpose which is giving energy but the health effects are mostly forgotten.  The health effects can range from mild to severe or even dead. Even with all the health issues, the energy drink market will increase to about $21 billion in annual sales by the end of 2017.

The health effects of energy drinks are cardiac arrest, headaches, type 2 diabetes, vomiting, high blood pressure, increased anxiety, insomnia, risk behaviour and nervousness. It has been reported in the United States that due to energy drinks there have been 18 deaths, 150 serious injuries and the number of hospital beds doubled, from 2004 to 2012. The health issues of energy drinks are clear but still the consumption of it, keeps increasing and reasons might be that people either ignore the facts or they need to be educated. In the United States, the consumption of energy drinks have always been on a rise and it is expected that from 2014 to 2019 it will increase up to 52%, which is an enormous amount.  

Energy drink volumes

Image source: Market Realist

Internationally, energy drink market has raised by 15% and will continue to increase. Surprisingly, the largest consumer is Latin America and interesting North America is the second lowest.

Energy Drinks Shows Impressive Stamina

The customers of energy drinks are almost everyone ranging from teenagers, adults and maybe even kids. Also, it is consumed by male and female. It is found that 66% of energy drink consumption are by people ages 13 to 35. But it is considered that males consume it more than females. In a study by Nowak and Jasionowski, they had 1481 female and 1148 male participants from which they concluded that males usage of energy drinks are higher than females. It was found that 60.8% females and 74.5% males, consumed energy drinks. An interesting fact found in the study was that about 21% of teenagers took energy drink for no specific reason whereas it is mostly taken for the reasons of tiredness, physical activity or caffeine consumption. 

One sad story related to energy drinks was in the case Lanna Hemann, a 16-year old who died from consuming the drink while being on vacation without her parents. To make the long story short, she consumed an energy drink from which she went into cardiac arrest and passed away.

In conclusion, the consumption of energy drinks is related to many health issues which may result in even death. With the increase in energy drink market, it possesses a risk to everyone but especially young people because they might not be aware of the health effects. Therefore, avoiding energy drinks completely is the best way to live a healthier life.

 

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source: National Science Teachers Association

March 14th, 2016

Hamed Hussaini

Stem cells used after cataract surgery for regenerating functional human lenses

Congenital cataracts are a significant cause of blindness in children. Congenital cataracts are the clouding of lens, which usually occurs at birth or shortly later; they do not allow any light to the retina or visual information to the brain, which results in a visual impairment. The function of the retina is to convert light energy into signals that are carried to the brain and processed as visual information in the brain.

Human eye schematic

This is a schematic of a human eye done by Rhcastilhos

This is a cataract in a human eye taken by Dr. Rakesh Ahuja.

This is a cataract in a human eye taken by Dr. Rakesh Ahuja.

Humans are born with cells in their eyes called lens epithelial stem cells (LEC); the function of these LECs are to create replacement lens cells throughout their lifetime. Currently, cataract surgeries remove, in an attempt to remove the cataracts, almost all the LECs too. The problem, with these current surgeries, is that the LECs regenerate in a way that doesn’t heal or reconstruct the actual lens properly.

A new study addresses these issues exactly. Researchers from the University of California, San Diego School of Medicine, and Shiley Eye Institute, with colleagues in China, have discovered a new surgical technique that retains the shape of the lens, with a therapy that stimulates the LECs to grow. The first part of the surgery has the same method of removing congenital cataracts, however it is the latter part that makes the difference. The second part is a therapy that permits the remaining stem cells to regrow into functional lenses.

This video by wochit News on youtube.com describes the new study and the use of the new surgery technique in the future.

https://www.youtube.com/watch?v=JeHIlKEs8_s

This technique was tried on animals first, followed by a small human trial that involved 12 infants under the age of 2. There was a control group of 25 infants (also under the age of 2) that received the original cataract surgery (the one without the therapy). At the end of the study, the infants of the control group had higher inflammation, more hypertension and increased lens clouding relative to the treatment group.

This proves that this new is a safer and more effective cataract surgery technique that is showing positive results and will potentially be the future of cataract surgery. The patients, particularly infants, will have now have healthier lenses forming after having their cataracts removed and will allow them to live a life with healthy eyes and proper vision.

 

Done by: Karanvir Gill