Promising Lead to a Universal Flu Vaccine

It’s flu season. Every year people get vaccinated against the flu, also known as influenza. Now, researchers are looking at a long-lasting flu vaccine that does not need to be given annually.

Tylenol

– Image Source: Dennis S. Hurd, Flickr

A recent study shows that scientists may have found a new potential target to generate new vaccines against certain types of the flu. They focused on a protein called hemagglutinin found on the surface of viral influenza particles. This protein contains a head region, which undergoes constant genetic changes, as well as a stem region that does not change. Although current influenza vaccines are composed of the viral particles from the head region, researchers discovered a way to stabilize the stem region in order to create a vaccine. Their results showed that vaccinated mice and ferrets either had reduced symptoms or complete immunity against certain related influenza viruses.

A vaccine is produced from taking a virus and weakening it so that it is unable to replicate and cause harm within an individual. When the vaccine is injected, the body is tricked into thinking that the virus particles are dangerous, thus initiating an immune response and producing antibodies that destroy that specific virus particle. As a result, these antibodies reside in the body for long periods of time. Therefore, if in the future the real virus enters the body, you will have specific antibodies to protect you from the virus.

– Credit: TED-Ed

Although a new flu vaccine is produced every year, the effectiveness of the vaccine may vary. Each flu season, because the virus is constantly changing, researchers try to determine the specific types of influenza that are currently circulating and those that will be present in the coming year. Based on this information, a vaccine is produced consisting of multiple types of the virus, however, it is impossible for the vaccine to be 100% accurate. With the discovery of this new target area on hemagglutinin, it could lead to the production of one vaccine for a group of related influenza viruses.

– Credit: Discovery News

According to the Government of Canada, approximately 10-20% of the population becomes infected with influenza annually. Flu symptoms typically include fever, cough, and aches. Furthermore, there are 12,200 hospitalizations and 3,500 deaths each year. Individuals at greater risk for complications or hospitalization caused by the flu include people with other diseases and weakened immune systems, residents in chronic care facilities, people aged 65 or older, and pregnant women. Immunize BC emphasizes the importance of everyone getting vaccinated in order to prevent the spread of disease to others. Researchers are hoping that a longer-lasting flu vaccine will encourage more people to get vaccinated, and also reduce the cost associated with producing and administering seasonal flu vaccines.

However, we may still have to get our yearly flu shots for quite some time. Researchers, although very optimistic about the future of creating a new long-lasting vaccine, say that more research needs to be done to determine the efficacy in human models.

– Brian Infanti

The Reality of Organic Food

We always see the sign in the produce section of our grocery stores: “organic”. Is it truly healthier than conventional produce? In recent years, the push to produce naturally grown foods has increased to boost the health of society as a whole. The term “organic” is thrown around to define foods grown with natural rather than synthetic pesticides and fertilizers but that doesn’t necessarily mean it’s a better alternative.

https://www.flickr.com/photos/enerva/482353822/in/photolist-JCbZd-or5MDX-9epP-cDqvGQ-7t29cE-FKEG4-axp2go-dtP6Gp-8c6xjg-prcsVW-kDZb92-dPH1Vy-cBbfoQ-faGYJF-afV9Ss-5t31X-8XXAMn-6cinXp-5h24Yo-i4QnyN-do5Y3U-eYts13-d39Sj-9xWLwf-acfK8D-7WPS1K-raEpZM-sH5w5x-7YSsux-ijrqPw-dkur6q-pj6oVJ-8G6kL7-rVXWy-k9ug69-faXdfb-oDokQi-t3nGqc-faH8rX-f4HeE7-kFDsDV-faH77K-faHhDR-dgt2x2-6URP9Q-495BkB-734KUo-ca2U9u-cLMhsu-7i7T3F

It is true that organic farms have 97% less synthetic pesticides than conventional farms, but that 3% is still there. This amount is brought to organic farms via wind transport and river runoff. Although synthetic pesticides are more spoken about, they aren’t the only potentially harmful compounds in our fruits and vegetables. Naturally, plants produce pesticides used to protect them from predators. These pesticides are found to be carcinogenic in rats and may be harmful to humans. Synthetic pesticides may actually reduce the production of the naturally occurring plant pesticides which leads to conventionally grown produce having lower levels of it than organic produce. Natural pesticides are found 10,000 times more than synthetic pesticides in both organic and inorganic foods. Moreover, the use of fertilizers in cultivation is essential in plant growth. Naturally occurring phosphate rock is used as a fertilizer in organic farming rather than synthetic fertilizers. The organic fertilizers actually contain more Cadmium, a known carcinogen, than synthetic fertilizers.

organic sticker

With all this research into how many synthetic vs organic compounds are used in the production of our food, it seems like either way, we re ingesting harmful chemicals every day.  Because the risks associated with synthetic pesticides have been more studied than organic pesticides, we are swayed into believing that organic foods are completely healthy. Without knowing the risks attached with organic pesticides and fertilizers, society does not know the full extent of the benefits and drawbacks of consuming organic foods. So before paying the extra couple of dollars for the foods with the organic label, it’s really worth your time to step back and think about what “organic” really means.

Author: Parvin Pabla

 

 

Type 1 Diabetes: A Potential Cure?

Type 1 Diabetes, also known as diabetes mellitus type 1, is a condition characterized by the impaired ability of one’s pancreas to produce insulin. In an individual with type 1 diabetes, the immune system malfunctions and attacks the beta cells of the pancreas, which are responsible for producing insulin. This classifies type 1 diabetes as an autoimmune disease, which is where the immune system attacks the body, thus it is currently incurable. The current treatment for this condition involves daily injections of insulin to allow the individual to regulate their blood sugar levels. Unfortunately, insulin therapy has side effects, such as hypoglycemia (low blood glucose levels) or hyperglycemia (high blood glucose levels) from incorrect dosages, and some individuals may be allergic to the preservatives added to insulin medication. Furthermore, insulin therapy involves precise control of blood sugar levels, and this is very difficult to achieve, often causing patients to face long-term medical problems as a result.

Diagram of the pancreas and beta cells. Via Wikimedia Commons.

Diagram of the pancreas and beta cells. Via Wikimedia Commons.

So what is this new potential cure? It began in 2014, when a team of Harvard University researchers used human stem cells, unspecialized cells that can become cells with a specific function, to create new beta cells in large quantities, as published in Cell. This new technique of creating insulin producing cells from human embryonic stem cells was a big step in diabetes research. In further experiments, these beta cells were transplanted into diabetic mice, as an attempt to replace the destroyed beta cells. Unfortunately, the immune system in the mice destroyed these new beta cells as well.

The experiments were first done on lab mice. Via Wikimedia Commons.

The experiments were first done on lab mice. Via Wikimedia Commons.

A team of researchers from MIT and several other institutions have devised an “invisibility cloak” for the beta cells, so they can hide from the faulty immune system. The cloak is composed of modified alginate, which is a material isolated from brown algae. After testing 800 various derivatives of this alginate capsule, they chose the best capsule from the tests, known as triazole-thiomorpholine dioxide (TMTD). This research was shown in a recently posted article in the Nature Biotechnology journal.

Brown algae that form the alginate used in "invisibility cloak". Via Wikimedia Commons.

Brown algae that form the alginate used in “invisibility cloak”. Via Wikimedia Commons.

The results were incredible! As a study in Nature Medicine showed, the injected mice were able to produce insulin until the implants were removed 174 days later. This has massive implications for diabetes therapy, as not being dependent on insulin injections is the end goal. If these implants were able to function in humans, then the diabetic individuals would not require insulin injections anymore. The next step of research is to move from trials on mice to trials on primates. If the tests on primates show positive results, the step after would be human trials. Researchers are making large strides towards a cure for type 1 diabetes.

– Kush Khanna

Eating Turkey Makes You Sleepy: True or False?

https://www.youtube.com/watch?v=aa1_CeUAQIc#action=share

Many of us have probably heard or even experienced the famous phenomenon known as food coma. If you have no idea what food coma is, you most probably have experienced it before unknowingly. Food coma is a state of lethargy or sleepiness experienced after consuming a large portion of food. Despite its informal name, it is a medically recognized condition called post-prandial comnolence.

Food coma generally hits harder at the most festive times of the year- the holiday seasons. The thanksgiving turkey is no exception. You stack your plates with turkey, sweet potatoes, dressing, cranberries and all the other old-fashioned foods, then fill your stomach up to the brim. Then, of course, you go for a second, then third round. It’s the holiday seasons after all. Not long after, you start to feel lethargic, energy-less and sleepy. Unknowingly, you have fallen into the food-coma trap.

For many years, urban myths have blamed the turkey for the main cause of the sleepiness. But is the turkey really to be blamed?

Where did the myth come from?  Many of you might have heard about the amino acid called tryptophan. Tryptophan is one of the components of the hormone serotonin. Serotonin is converted to the sleep-inducing hormone melatonin. Without melatonin, we will all be always wide awake. This chemical is essential in our body to give us enough rest at night for proper bodily functions. Hence, yes, tryptophan is an essential chemical in our body. However, our body does not produce tryptophan. Tryptophan is obtained by our body from the food we eat.

The tryptophan we ingest competes with other amino acids in our body to enter our brain through the blood-brain barrier. The blood-brain barrier is an interface that separates the brain from the rest of the body. It protects the brain from harmful chemicals that enters the body by filtering them. The blood-brain barrier will only allow certain chemicals to enter the brain. Only a portion of the tryptophan we ingest successfully enters our brain. Most of them are broken down in our liver. The myth that turkeys make us sleepy began when tryptophan were found in turkey meat.

So, do turkeys make us sleepy? The answer to this question is- yes and no. Turkey meat contains tryptophan-yes. However, according to Standford neuroimmunologist Lawrence Steinman, MD, the levels of tryptophan  in turkey “is not higher than in most other muscle tissue from other animals, more commonly known as meats”. It is not the turkey that makes us sleepy but it is the enormous amounts of carbohydrates and often alcohol consumed on the holiday seasons.

Carbohydrates such as the dressing or mashed potatoes induces the release of insulin into the bloodstream compared to other amino acids present. As a result, higher levels of tryptophan are concentrated at the brain-blood barrier.

In conclusion, it is not the turkey that makes you sleepy after Thanksgiving. So, take a quick nap on Thanksgiving, but be sure to wake up in time for the dishes!

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The Outbreak of the Zika Virus

Although not a new illness, Zika is currently spreading at an alarming rate in Central and South America, a tropical disease that is caused by the Zika virus. Zika is spread primarily by an infected Aedes aegypti female mosquito, where the mosquito becomes infected by biting a person already infected by the virus. The Zika virus is in the same family as yellow fever, dengue fever, and the west nile virus and is known to cause mild symptoms such as a rash, headaches, fever, and pink eye. In fact, Centers for Disease Control and Prevention (CDC) says only 20% of those infected will get sick.

Aedes aegypti mosquito. Credit: James Gathany

So if this illness is mild, then why are we concerned? On top of the fact that more than a million people have already been infected in Brazil, there is now evidence that Zika may be linked to birth defects in unborn infants. Scientists say that pregnant woman who get infected could pass this virus to their child, causing the fetus to develop microcephaly, a small brain and head abnormality. New York Times stated that more than 4,000 cases of microcephaly have been registered in Brazil. Hawaii’s Department of Health has also confirmed USA’s first microcephaly case linked to the Zika virus. Moreover, The Vancouver Sun has reported 2 confirmed cases of Zika in B.C. residents. With no treatment or vaccine available, there have been growing concerns for its appearance in North America.

MRI’s of a normal individual (left) and a patient with microcephaly caused by an ASPM mutation (right). Credit: Public Library of Science (PLOS) Biology

World Health says that the virus will likely spread to regions of Central, South and North America with the exception of Chile and Canada, as the type of mosquitos that spread the Zika virus are not present in these two countries. It is also important to note that the Zika virus isn’t necessarily being transmitted in North America but it is infected people that are returning from Brazil and Mexico for example, who are bringing the disease to Canada and the United States. Researchers are predicting that Zika will likely follow the same pattern as dengue fever in the US, hitting the hardest in the hotter months.

It is important to educate the public about Zika and advise pregnant woman to postpone their travels to these countries where they could possibly become infected.

When trying to prevent getting infected by this virus, the most important prevention methods revolve around mosquito bites, as this is the most common way this virus spreads within a population. The following are therefore critical when you are in a location where this virus is found: wearing long-sleeve clothing, sleeping with a mosquito net, and most importantly, using insect repellant.

The video below by CNN explains the possible spreading of this virus, along with the concerns about pregnant woman with the Zika disease.

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-Daniela Castillo

Can First Nation’s clay be used in hospitals to kill antibiotic resistant bacteria?

As more empowerment and resources comes to First Nations group, new discoveries and technology may soon become available for use in a variety of settings.

In this article, a clay from Kisameet Bay, British Columbia, used by First Nations for centuries for its healing properties have been used in lab tests to kill antibiotic-resistant bacteria.

Antibiotic-resistance bacteria has proven resilient and a danger to the population, particularly in hospital settings where there is a growing problem due to overuse of antiobiotics. This video highlights the microbiology of antibiotic resistance in bacteria.

The research was published in the American Society for Microbiology’s mBio journal. Rare mineral clay is recommended to be studied as a treatment for serious infections caused by the so-called ESKAPE pathogens, which cause the majority of hospital infections and the effects of antibacterial drugs.

The acronym ESKAPE comes from the scientific names of the bacteria themselves:

  • Enterococcus faecium.
  • Staphylococcus aureus (also known as as the methacillin-resistant superbug MRSA).
  • Klebsiella pneumoniae.
  • Acinetobacter baumannii.
  • Pseudomonas aeruginosa.
  • Enterobacter species.

However, further studies and testing will be required before this clay can be made for hospital use.

I think this is an interesting breakthrough, not only for science/technology/healthcare, but for Canadian-First Nations relations. Reconciliation can take on many different forms, but with combined effort on both sides, something wonderful can be achieved.

 

Are E-Cigarettes truly harmless?

Man using E Cigarette indoors. Credit: Vaping360.com

Man using E Cigarette indoors.
Credit: Vaping360.com

The trend of “vaping” via  E-Cigarettes has exploded over the years. A fad that has quickly spread across a variety of age groups may now be a potential health hazard. An average user of an E-Cigarette may not consider that the vapour they are inhaling is harmful to their body. It can’t possibly be toxic since it’s not real cigarette smoke, right? Unfortunately, this isn’t the case. The lack of data linking E-Cigarettes and heath concerns has been the main reason why the general public deems they are safe and why they aren’t as strictly regulated as regular cigarettes. The way the E-Cigarette has been handled by the government regarding health concerns is quite nostalgic of how normal cigarettes were treated 60 years ago. Cigarettes were thought to be safe until many years later cases of cancer were popping up left and right. The ultimate question raised is, will these E-Cigarettes pose a serious health concern in the future?

A recent study conducted by Harvard T.H School of Public Health tested 51 E-Cigarette refill liquids for diacetyl, 2,3-pentanedione, and acetoin. Diacetyl  has been linked to causing “popcorn lung“, a serious lung disease that is commonly treated by a lung transplant. Furthermore, the other 2 chemicals acetoin and 2,3-pentanedione have both been recognized as respiratory hazards in a public workplace. The researchers of the study found that 47 of the 51 liquids tested contained one of these compounds. These results don’t necessarily mean that all refill liquids possess these compounds, but a majority of them do.

Another article posted by Heather Buschman of University of California discusses a study conducted that focuses on how E-Cigarette vapour kills cells in the airway of mice and makes bacteria more virulent. In the study, two groups of mice were treated with an antibiotic-resistant bacteria with one group exposed to E-Cigarette vapour while the other group was not. The results indicated that 25% of the mice that had been exposed to the E-Cigarette vapour and the antibiotic-resistant drug had died due to the bacteria being more virulent. The researchers of the study show that E-Cigarette vapour can also potentially have negative indirect effects on subjects other than just causing lung disease, such as making bacteria more virulent and thus creating multiple concerns that weren’t present before.

Both studies mentioned have come to a conclusion one way or another that E-Cigarette vapour is not completely harmless. Hopefully in the future more research will be conducted resulting in conclusive evidence that changes the stigma of “harmless vaping”.

The video below by AsapSCIENCE compares traditional smoking and E-Cigarettes. By comparing the harms associated with both, the video explains how due to the lack of current data we won’t know the extent of the harm caused by E-Cigarettes until the future, although studies being conducted don’t indicate a bright future for these technological fads.

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Credit: AsapSCIENCE

 

Posted by Harsh Bhatt

Detecting early for bowel cancer

Gastroenterologist performing a colonoscopy on a patient.

Gastroenterologist performing a colonoscopy on a patient.

Always better to be early than too late, whether you be arriving at a party early or lining up for Boxing Day sale. However, this is especially the case with most cancers. When it is diagnosed as the final stages, it may be too late for action to take place. Thankfully, screening for bowel cancer has become a major role in detecting early for bowel cancer patients.

Of the cases picked up by bowel screening, 37% were caught in the early stage while 8% were already in the advanced stage. This compares to 40% of bowel cancers diagnosed as an emergency being stage four and 22% of bowel cancers in stage four by the time the doctors diagnosed them.

Here, we see a clip of a colon screening done on a patient. The video highlights three main screening options that are available to patients depending on frequency, cost, and invasiveness: fecal occult blood test, flexible sigmoidoscopy, and colonoscopy. All three have their own advantages and disadvantages in screening for cancer. However, out of the three, colonoscopy is considered the best and most effective method for detection of polyps.YouTube Preview Image

Diagnosis at an early stage means better chances of survival due to faster and more effective treatment before the cancer may spread to other areas of the body.

In the case of targeting bowel cancer and in general, all types of cancers, understanding the impacts of technology and advancement can help us manage our resources more efficiently in hopes of saving more lives before it gets too late.

 

Posted on January 27, 2016 by Lorraine Yu