The Link Between Calcium Channel Insertion and Changing Secretion

Do you or someone you know suffer from diabetes? If so, you may know that this disease is a result of decreased insulin secretion from the pancreas. Decreased secretion of hormones like insulin may have detrimental effects on an individual. For this reason, researchers have conducted experiments in an attempt to understand how secretion works.

Dr. Christopher Groten, who is currently conducting research at the University of British Columbia, has found that the insertion of new additional calcium channels (Cav2) into the membrane of cells increases secretion of hormones. Specific to Dr. Groten’s research, the model organism Aplysia californica secretes a hormone called egg-laying hormone (ELH). This hormone is released upon activation of a particular enzyme called PKC.

https://youtu.be/SATOrk6w7-M

Credit: Brian Infanti

Often the transportation of calcium across the membrane occurs in response to a stimulation. However, the process involved is not well understood. Therefore, observing an organism with a simpler nervous system, such as Aplysia californica, allows researchers to better understand this mechanism by which calcium enters the cell. Correspondingly, Dr. Groten uses A. californica in his research because he believes that “Aplysia is a good organism to study because the behaviour is really well known, and it has a reduced nervous system”. Essentially, calcium channels are important for carrying out many vital processes in our body. Below, you’ll find a clip that might help answer a few questions about calcium channels in general.

https://soundcloud.com/brian-infanti/so-group-6-podcast

Credit: Brian Infanti

According to the podcast, there are many diseases associated with calcium channel deficiencies. Another study shows how specific areas of cells are associated with increased calcium channels and increased secretory vesicles. As a result, this leads to greater release of hormones. Perhaps a connection between calcium channel insertion and regions with lots of secretory vesicles can be made by relating this particular study to Dr. Groten’s findings in order to lead to other therapeutic strategies for various diseases.

As world population increases and diseases such as diabetes become more prevalent, further resources are required to improve research. For instance, Public Health Agency of Canada reported spending $15 million in the past 4 years on funding for the National Population Health Study of Neurological Conditions. With this type of funding in the public health sector, research like Dr. Groten’s can help lead to new discoveries that benefit the public.

– Paria Assadipour, Daniel Kim, Brian Infanti

Polymers with the Ability to Glow

Science has many applications to our everyday lives which go unseen. From the moment the alarm clock wakes you up, to the moment you turn off the lights to go to bed, science is directly impacting your life.

You may be surprised to find out that a chemistry study in its early stages may have great implications for the situations you experience on a daily basis.

Benjamin Rawe, a chemist  at the University of British Columbia, has been studying polymers that have phosphorus in their backbone. This study produced a polymer which can glow!

But what are polymers? In essence, polymers are repeating units made of monomers, which are individual molecules. Using these polymers, Dr. Rawe added phosphorus to the them. Phosphorus is an element with very interesting properties because it can react with many things. When this element is incorporated into the polymer backbone it fluoresces, which means that it can glow. It is easy to think of  the phosphorus like a switch for the polymer. So based on what is attached to the phosphorus, you’re either turning on or turning off the fluorescence.

The video below explains in detail what polymers are and the properties of phosphorus that make it essential to this study.

Credit: Daniela Castillo & Vanessa Sidhu

The real-life application for these polymers that contain phosphorus is the possible ability for them to be used as sensors. Sensors are objects that detect an event or change, and respond to that change. Sensors are required for many parts of our daily lives, they are used in thermometers to measure your fever, the light that turns on when you walk by, and even the metal detector used at airports. Furthermore, the Global Positioning System (GPS) and smartphones are technologies that are on the uprise. The potential application for more efficient sensors in these items could help enhance these technologies even more.

The podcast below gives examples of sensors and their importance in our growing population.

Credit: Kush Khanna & Siriwat Chhem

The research on this topic is just getting started, there is much more to study and discover. Benjamin continues to learn more about the polymer he has created and the significance it can have in our society.

– Vanessa Sidhu, Daniela Castillo, Kush Khanna and Siriwat Chhem

Understanding Absence Epilepsy

Did you know that epilepsy is the fourth
most common neurological problem of our society?

Epileptic seizures are the result of abnormal activity in the brain. Source: Youtube

Epileptic seizures are the result of abnormal activity in the brain. Absence epilepsy is one form of epileptic seizures, characterized by a momentary loss of awareness, usually lasting less than ten seconds. What differs an epileptic seizure from a non-epileptic seizure is that it is recurrent and non-epileptic seizures may be induced by psychological issues or stress-related factors.

Absence epilepsy is often associaed with children who have trouble in school, social problems, or who misbehave often. Source: Flickr

Absence epilepsy is often associated with children who have trouble in school, social problems, or who misbehave often. Source: Flickr

This condition is more common among children than in adults. As a result, absence seizures are often mistaken as daydreaming or periods of blanking out. Symptoms of absence seizures include fluttering eyelids, smacking of the lips, or rubbing fingers together. Absence epilepsy is often associated with children who have trouble in school, social problems, or who misbehave often. Most children will outgrow their seizures by age 18, however in some cases they can continue throughout the rest of their lives.

To understand a bit more about absence epilepsy, the podcast below depicts a scenario of a child experiencing absence seizures and how current research will fuel further medical studies to help with this disorder.
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There are current studies being conducted on the causes of this condition at the University of British Columbia, and we interviewed Dr. Stuart Cain at the Djavad Mowafaghian Centre for Brain Health about his research on absence epilepsy.

The main focus of Dr. Cain’s research is on calcium channels in the brain, and the role they play in absence epilepsy. It is found that the overactivity of certain calcium channels located specifically in the cells of the brain leads to a phenomenon known as “burst-firing”, and this is thought to be what triggers absence seizures.

The causes of absence epilepsy are still unknown, although there are many theories as to what causes an absence seizure. Dr. Cain believes that when overactive brain cells in one specific region communicates with two other regions of the brain and causes them to be stuck in a synchronous loop; this is what causes absence epilepsy.

The video below explains further on how absence seizures occur, and what the main findings of Dr. Cain’s research were:
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There are currently two types of drugs available to treat absence epilepsy, and although they work for most people in stopping absence seizures from occurring, they have not been shown to be 100% effective.

Dr. Cain and his team of researchers’ study serve as foundation for further development of anti-seizure medications to control absence seizures. He believes that in order to find a drug that will be completely effective in controlling absence seizures, the drug will need to target the calcium channels in the brain which cause burst-firing. Dr. Cain suggests that the next move is to push pharmaceutical industries to create a drug capable of doing just that. If this proves to be successful, perhaps then children will not have to worry about absence epilepsy affecting their lives.

Posted on April 4, 2016
By Emma Peachey, Jenny Ung, Karanvir Gill, Harsh Bhatt

Eco-friendly Hydrogen Fuel Cells

Recently we have been hearing a lot about hydrogen fuel cells and the possible applications where they can be used, specifically in automobiles, but what exactly are they and why are they considered eco-friendly?

A fuel cell is a device that is able to harness the energy stored in the chemical bonds of molecules. Hydrogen fuel cells, in particular, get this energy from the bonds in Hydrogen (H2) and Oxygen (O2) gas. On one side of the cell, H2 is pumped in. On the other side of the cell O2 is pumped in. Separating these two sides are a proton permeable membrane. The function of this membrane is to allow protons to pass through while blocking the pathway of electrons, thus effectively harnessing this electrical energy.

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These cells are considered environmentally friendly because of the “waste” they produce. While most sources of power produce carbon dioxide gas (CO2) as a byproduct, hydrogen fuel cells produce water and excess O2 and H2. These products can be easily used as sources for other processes and are harmless if left in the environment. Further, the chemicals required for this process can be synthesized or collected very efficiently. O2 is readily available and attainable in the air we breathe. There are many pathways for H2 production. A very environmentally friendly way is through harnessing the H2 produced by microorganisms such as algae through biological processes. These processes of attaining fuel for energy production are very eco-friendly when compared with oil mining which is used to extract petroleum for energy on a large scale.

2014 Toyota FCV Hydrogen Fuel Cell Vehicle

Hydrogen fuel cell concept car by Toyota via. flickrcommons

Overall, hydrogen fuel cells provide the world with a very environmentally friendly way to produce energy we use everyday. If we can begin to use this technology on a large scale to replace current methods, we can effectively decrease the amount of pollution we put into our environment everyday while still quenching our energy needs.

Author Parvin Pabla

 

 

 

 

Poisonous Potatoes? Your Spuds Can Kill You!

Potatoes are a staple food in North America and many other places of the world, but did you know this spuddy delight could possibly kill you? In 1978, a large group of boys in a school suffered from severe diarrhea and vomiting. 17 of them even required to be hospitalized and the 3 most severely affected children were even comatose. The cause? Eating a significant amount of toxic potatoes.

But how could potatoes, something the entire world eats nearly everyday cause such a ruckus? Well, potatoes as we consume them are generally not toxic. However, old potatoes that have started turning green start to produce a toxin called Solanine. Generally, people feel that it is a waste to throw away food and may possibly eat a potato that has slightly turned green, but eating too many of these could possibly destroy your digestive system!

A study evaluating the toxicity of solanine found that when rabbits were administered solanine, they encountered breathing difficulties and partial paralysis of limbs. Some were eventually found to be dead.  The results of this study highlight how important it is to be mindful of any leftover potatoes that have started turning green or even started budding; it is safer to throw these away rather than risk your personal health just to save a few dollars.

It is very important that more people be informed about this because almost every household in North America consumes potatoes and young children, who are more susceptible to lower doses of toxins are at risk here. Unknowing parents could possibly cook up some greening spuds which, at lower doses may not affect them but could possibly cause their children to fall severely ill. 

So, the next time you find a potato that has been left for too long, despite how hungry or strapped for cash you are, please remember that you risk paying a much higher price for eating it than you would throwing it away. However, why should I pick on the potato only? Below is a video showing other commonly consumed items that pose just as much, if not more of a risk than the potato.

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