Author Archives: danh

Would you like to sequence your genome?

Imagine a world where you are able to gain access of your entire genome within minutes. Not only will you become aware of what makes you unique, but it will also help with the diagnoses and treatments of many diseases. Thanks to next-generation sequencing technologies like Illumina and 454, we are one step closer to converting this fantasy into a reality.

Next-generation sequencing technology: Illumina. Author: Dr. Corey Nislow, used with permission.

Currently, these new technologies have the ability to sequence five human genomes in one week. This is astonishing because each genome is around 4.3 meters long with over 20,000 genes that code for proteins. Given its efficiency with deciphering human DNA, you would expect high performance on bacterial and archaeal microorganisms that have smaller genomes. By determining their genetic information, it is possible to compare different types of DNA and look back on the evolutionary origin of these life forms.

Check out this podcast to learn more about the evolutionary background of Bacteria, Archaea, and Eukarya:

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A study done by Dr. Nislow and his colleagues has demonstrated the usage of next-generation sequencing, particularly Illumina. They compared the structure and function of chromatin, a DNA- protein complex which contains genetic information, in Archaea and Eukarya by sequencing their genomes. The video below gives a more detailed overview of the research:

YouTube Preview Image Youtube user: stephanieem (SCIE 300 Group 1)

In addition to their rapid sequencing speed, these new technologies have other advantages over the conventional methods. Not only are they highly accurate, but they also provide a larger amount of data for a lower price. For example, when using Illumina, it costs around ten cents to sequence a million nucleotide bases, the fundamental units of DNA. Although this may seem a whole lot, each human cell has over 12 billion bases of DNA!

File:DNA chemical structure.svg

Picture of DNA showing the 4 different nucleotide bases. Author: Madprime via Wikimedia Commons

With the advent of the next-generation sequencing technologies, it is now possible to achieve many tasks that would otherwise remain unresolved. As they continue to become more advanced, many excitements in this field lie ahead. You never know, genome sequencing might even become an application on our computers where we will be able to see for ourselves what makes each one of us so unique.

-Group 1: Daniel (Sanggi) Hong, Stephanie Mrakovich, Maral Altanbadralt, Jing Xiang Yang

ACHOO syndrome: not your usual sneeze

When we step outside into bright light with other people, we can occasionally hear someone sneezing. Is this merely a coincidence? Or is there a possible explanation for this? It turns out that this desire to sneeze after looking at an abrupt bright light occurs in about a third of the world’s population.

Photo of a man sneezing. Author: James Gathany via Wikimedia Commons

This surreal way of sneezing is called photic sneeze reflex, or, conveniently, ACHOO (Autosomal dominant Compelling Helio-Ophthalmic Outburst) syndrome. Despite being highly prevalent around the world, we know very little regarding this phenomenon. In fact, a study has found that victims of this reflex think this occurs in everyone, whereas “normal” people become bewildered when finding about its existence. This level of unawareness might be due to the little threat that this condition poses to those who have it.

YouTube Preview Image Youtube user: Thomas Denton

Due to the common occurrence of this condition within a family, it is generally regarded as an autosomal dominant trait, which simply means that it is likely for an affected parent to have an affected child. This is surprising, since the sneeze that we are all familiar with is acquired from environmental factors like viruses, regardless of how we are genetically shaped.

So how is it then that the sun or any other light sources trigger sneezing? Many theories were considered, with the first one dating back to Aristotle’s time. He speculated that the sun’s heat had a direct effect on the nose, causing it to become irritated and therefore induce sneezing. Clearly, this hypothesis was refuted later on, because the sneeze disappears if you close both eyes.

The most supported reasoning behind this involves the cranial nerves, particularly the optic and the trigeminal nerves. It is our trigeminal nerve that is primarily responsible for sending information that leads to sneezing to the brain. However, the complexity and the compactness of our heads allow this nerve occasionally picks up signals from the optic nerve. Thus, when some of us look at a bright light that stimulates the optic nerve, it is erroneously translated by the brain as the body’s need to sneeze.

Here is a video that gives a very simplified explanation:

YouTube Preview Image Youtube user: 2ManyVid3os

 

As I mentioned before, this condition is generally harmless to those who have it. However, it can still pose serious risks in certain situations. For example, it is common for drivers to get a sudden outburst of sunlight shone onto their eyes. Two-thirds of the population would squint their eyes and pull down the sun visors. The remaining third on the other hand, would experience an uncontrollable movement caused by the photic sneeze reflex. Considering that they are driving, you can imagine how dangerous that can be.

Although you may find it hard to believe, there is a perk to inheriting this condition. I am sure that all of us had a moment where we had a desire to sneeze, but was not able to produce it. However, this is not a problem for around 2.3 billion people, including myself, since we can deliberately produce a sneeze. Besides, who wouldn’t want to feel elevated, given that a sneeze is 1/8 of an orgasm?

-Sanggi(Daniel) Hong

ACHOO syndrome: not your usual sneeze

Have you ever experienced a desire to sneeze after looking at an abrupt bright light, like the sun? I know I have, along with about a third of the world’s population.

Photo of a man sneezing. Author: James Gathany via Wikimedia Commons

This surreal way of sneezing is called photic sneeze reflex, or, conveniently, ACHOO syndrome. Despite being highly prevalent around the world, we know very little regarding this phenomenon. In fact, a study has found that victims of this reflex, including myself, think this occurs in everyone, whereas “normal” people become bewildered when finding about its existence. This level of unawareness might be due to the little threat that this condition poses to those who have it.

YouTube Preview Image

Due to the common occurrence of this condition within a family, it is generally regarded as an autosomal dominant trait, which simply means that it is likely for an affected parent to have an affected child. This is surprising, since the sneeze that we are all familiar with is acquired from environmental factors like viruses, regardless of how we are genetically shaped.

So how is it then that the sun or any other light sources trigger sneezing? Many theories were considered, with the first one dating back to Aristotle’s time. He speculated that the sun’s heat had a direct effect on the nose, causing it to become irritated and therefore induce sneezing. Clearly, this hypothesis was refuted later on, because the sneeze disappears if you close both eyes.

The most supported reasoning behind this involves the cranial nerves, particularly the optic and the trigeminal nerves. It is our trigeminal nerve that is primarily responsible for sending information that leads to sneezing to the brain. However, due to the complexity and the compactness of our heads, this nerve occasionally picks up signals from other sources, like the optic nerve. Thus, when some of us look at a bright light that stimulates the optic nerve, it is erroneously translated by the brain as the body’s need to sneeze.

Here is a video that gives a very simplified explanation:

YouTube Preview Image

 

As I mentioned before, this condition is generally harmless to those who have it. However, it can still pose serious risks in certain situations. For example, it is common for drivers to get a sudden outburst of sunlight shone onto their eyes. 66% of the population would squint their eyes and pull down the sun visors. The remaining 33% on the other hand, would experience an uncontrollable movement caused by the photic sneeze reflex. Considering that they are driving, you can imagine how dangerous that can be.

Although you may find it hard to believe, there is a perk to inheriting this condition. I am sure that all of us had a moment where we had a desire to sneeze, but was not able to produce it. However, this is not a problem for around 2.3 billion people, including myself, since we can deliberately produce a sneeze. Besides, who wouldn’t want to feel elevated, given that a sneeze is 1/8 of an orgasm?

-Sanggi(Daniel) Hong