Category Archives: Outreach Project

The Two “E”s to Avoid Cancer: Exercise and Eat Well

Cancer is a mysterious silent killer whose cure, even to this day, cannot be found.  Many studies have found a link between weight gain and obesity to increased risk of cancer.  Could the solution to cancer prevention be something as simple as getting enough exercise and having a proper diet? As many of you know, the idea of following a healthy diet and exercising regularly is beneficial and we are constantly reminded by our friends, family and even the media. However, unknown to many of us, what we think is a common idea may be very effective in preventing obesity-related cancers.

Healthy Salad by Emilian Robert Vicol via Flickr creative commons

How exactly does being overweight relate to increased cancer risks you ask? Simply put, it has been hypothesized that many hormones or proteins involved in the development and progression of diseases such as cancer, are secreted by adipose tissue. Therefore, the more fat accumulated in the body, the more hormones secreted or “genes” expressed that can take part in the pathways leading to cancer. To examine the effects of weight loss on fat tissue gene expression and subsequently, the amount of hormones secreted, Dr. Kristin Campbell, a researcher at the University of British Columbia, and associates studied the effects of exercise and diet on body fat tissue. 

Dr. Kristin Campbell working with Scenery Slater, a cancer patient by Martin Dee via http://www.publicaffairs.ubc.ca/2012/06/06/blame-it-on-chemo-brain/

Forty-five postmenopausal women participated and were divided into 4 treatment groups: a control group (no treatment), a calorie-restricted diet group, an exercise group and a diet+exercise group. Blood and adipose tissue samples were taken from every participant before and after following the treatments for 6 months. The samples were then analyzed for changes in hormone levels or fat tissue expression in the body. It was found that women who followed only a calorie-restrictive diet lost the most weight and greater weight loss was correlated with greater changes in fat tissue gene expression. In other words, reducing the amount of body fat ultimately reduces the chances of developing diseases such as cancer.

How women were divided into different groups in the experiment

For further details on the motivation of Dr. Campbell as well as the findings of the research, take a look at the video below:

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Youtube via whywontmynamefit

Although the subjects were all postmenopausal women, Dr. Kristin Campbell notes that weight loss can also reduce the risk of colon cancers and other obesity related diseases that affect men and women equally. From the research findings, we can see how important being healthy is for not only older generations, but for the younger generations as well. We hope our blog motivates others to live a healthier lifestyle.

With that being said, listen to the podcast below for Dr. Campbell’s suggestions for exercise and diet regimes:

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– Grace Lam, Alice Lin, Ashkan Nasr, Derek Rejto

Robot Invasion?

With the drastic increase of technology in robotics in the past decade, should we be fearful robots will take our jobs in the future?

Robot apocalypse anyone?
(via Flickr: A.G Photography)

Posdoctoral research fellow Brian Gleeson in the University of British Columbia computer science department doesn’t believe so – his paper “Gestures for Industry” seeks to push the boundaries of human interactions with robots in a society where mass production is essential for satisfying the demand for goods by consumers.

Significant technological advancements in relatively short periods of time have not only resulted in better household goods, but have also extended to the production process itself. The use of robots in every nook and cranny of industrial assembly lines has allowed for faster, more efficient production of goods. However, over the years, the transition to more mechanized labour has come under fire from the human workforce – many fear for the security of their jobs.

This video below shows the progress of technology and robotics, and what this implies for job security:

YouTube Preview Image(Youtube via CurtMattack)

Technological advancements are showing no signs of slowing down, so are robots destined to take over the production process entirely?

Fortunately not, and many will take comfort in learning that the “Gestures for Industry” paper explores the integration of robotic assistants to increase efficiency, safety and to reduce stress on workers.

Dr. Gleeson has extensively studied human-human interactions, as well as human-robot interactions using only hand gestures to accomplish various tasks. Through this, they discovered that participants, human or robot, must know what the task is ahead of time. For example, knowing whether the task is placing a part in a specific location or manipulating multiple parts is imperative to fully understanding their partner’s hand gestures. Just like the human-human teams, the human-robot teams were able to perform these tasks that communicated specific details without any vocal, touch or eye communication. Dr. Gleeson’s research is one of the first stepping-stones towards human-robot interactions and the future implications of these findings are endless.

These are the types of one-armed robots Brian Gleeson and his team work on.
(via Wikimedia: Lionel Allorge)

The podcast below provides insight on Brian Gleeson’s study and delves into the future of robotics.

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While the field of robotics is undoubtedly advancing at a significant rate, human workers need not be concerned with being out of a job. Dr. Gleeson states that robots have already replaced humans in the workforce wherever possible, and that the next step to a safer, more efficient production process requires humans and robots to coexist and cooperate with each other, ultimately resulting in a higher standard of living.

On a side-note, a recent article from Forbes reports robots will actually create more jobs.

– Nicole Gehring, Harleen Kalra, Curtis Ma, Alvinesh Singh

Ozone: Friend or Foe?

Did you know that living in a city with with high levels of air pollution increases your risk of getting lung cancer by 20%? Every year humans are spewing more and more pollution into the Earth’s atmosphere with CO2 attracting the most attention. While CO2 has major effects on the Earth’s climate and subsequently our way of life, ozone is one pollutant that does not receive nearly as much attention as it should. The main view that the general public holds regarding ozone is its ability to block harmful sun rays which may cause skin cancer in humans. Although this is true, it mostly applies to ozone in the upper parts of the atmosphere. Ozone levels in the actual air we breathe has many negative effects that very few people know about.

Below is a recorded newscast of how ozone has affected the lives of many:

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Ozone-1,3-dipole by Benjah-bmm27 via Wikimedia Commons

Ozone is an oxidant which has harmful effects on biological life. At the University of British Columbia (UBC), Dr. Steyn, a professor of Earth and Atmospheric Sciences, has recently modeled past ozone trends in the Lower Fraser Valley using various computer simulations. To gain a better understanding of the issue, we interviewed Dr. Steyn about his study and the motivations behind his research. Steyn was interested in comparing past ozone trends with emissions, “to understand which part of the emission reductions have actually had the effect, and then for [policymakers] to use that to build the policy.” More often than not, various governments have rushed plans into action. For example, “Metro Vancouver has made two air quality management plans” that Steyn considers to be made “without  scientific guidance.” Therefore, he “deliberately framed the research in a way that the results could be used for policy…Metro Vancouver has a big process going to understand ozone and what reductions they need to make further.”

Here is a video outlining Dr. Steyn’s study of harmful ozone pollution  and its effects in the Lower Fraser Valley:

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SCIE 300 OUTREACH_SECTION 210_GROUP 2 by kyuuke1013SK

Although we have a clear idea of the present worsening ozone trends, there are still many difficulties, especially emission reductions. Society must strike a balance between the life of convenience that we are accustomed to and the general health of the public. In general Canada manages to  balance things  very well but areas like the Lower Fraser Valley have room for improvement. Our publicly funded healthcare system makes it possible for us to clearly and precisely determine what the cost of degraded air quality is compared to the cost of improving air quality in areas such as Fraser Valley; and we know that the cost of cleanup is a great deal cheaper than the health care costs.

This model is a tool that can be used by researchers and policy makers to increase our understanding of what must be done to ensure the best air quality possible. The health problems that arise from pollutants such as ozone must be avoided at all costs. Progress towards this goal has been made, but there is still much more that needs to be done before we can take a deep sigh of relief!

– Alex Gibson, Stella Meng, Earvin Remandaban, Christine Wong

 

Would you like to sequence your genome?

Imagine a world where you are able to gain access of your entire genome within minutes. Not only will you become aware of what makes you unique, but it will also help with the diagnoses and treatments of many diseases. Thanks to next-generation sequencing technologies like Illumina and 454, we are one step closer to converting this fantasy into a reality.

Next-generation sequencing technology: Illumina. Author: Dr. Corey Nislow, used with permission.

Currently, these new technologies have the ability to sequence five human genomes in one week. This is astonishing because each genome is around 4.3 meters long with over 20,000 genes that code for proteins. Given its efficiency with deciphering human DNA, you would expect high performance on bacterial and archaeal microorganisms that have smaller genomes. By determining their genetic information, it is possible to compare different types of DNA and look back on the evolutionary origin of these life forms.

Check out this podcast to learn more about the evolutionary background of Bacteria, Archaea, and Eukarya:

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A study done by Dr. Nislow and his colleagues has demonstrated the usage of next-generation sequencing, particularly Illumina. They compared the structure and function of chromatin, a DNA- protein complex which contains genetic information, in Archaea and Eukarya by sequencing their genomes. The video below gives a more detailed overview of the research:

YouTube Preview Image Youtube user: stephanieem (SCIE 300 Group 1)

In addition to their rapid sequencing speed, these new technologies have other advantages over the conventional methods. Not only are they highly accurate, but they also provide a larger amount of data for a lower price. For example, when using Illumina, it costs around ten cents to sequence a million nucleotide bases, the fundamental units of DNA. Although this may seem a whole lot, each human cell has over 12 billion bases of DNA!

File:DNA chemical structure.svg

Picture of DNA showing the 4 different nucleotide bases. Author: Madprime via Wikimedia Commons

With the advent of the next-generation sequencing technologies, it is now possible to achieve many tasks that would otherwise remain unresolved. As they continue to become more advanced, many excitements in this field lie ahead. You never know, genome sequencing might even become an application on our computers where we will be able to see for ourselves what makes each one of us so unique.

-Group 1: Daniel (Sanggi) Hong, Stephanie Mrakovich, Maral Altanbadralt, Jing Xiang Yang