Category Archives: Science in the News

Ozone: Friend or Foe?

Did you know that living in a city with with high levels of air pollution increases your risk of getting lung cancer by 20%? Every year humans are spewing more and more pollution into the Earth’s atmosphere with CO2 attracting the most attention. While CO2 has major effects on the Earth’s climate and subsequently our way of life, ozone is one pollutant that does not receive nearly as much attention as it should. The main view that the general public holds regarding ozone is its ability to block harmful sun rays which may cause skin cancer in humans. Although this is true, it mostly applies to ozone in the upper parts of the atmosphere. Ozone levels in the actual air we breathe has many negative effects that very few people know about.

Below is a recorded newscast of how ozone has affected the lives of many:

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Ozone-1,3-dipole by Benjah-bmm27 via Wikimedia Commons

Ozone is an oxidant which has harmful effects on biological life. At the University of British Columbia (UBC), Dr. Steyn, a professor of Earth and Atmospheric Sciences, has recently modeled past ozone trends in the Lower Fraser Valley using various computer simulations. To gain a better understanding of the issue, we interviewed Dr. Steyn about his study and the motivations behind his research. Steyn was interested in comparing past ozone trends with emissions, “to understand which part of the emission reductions have actually had the effect, and then for [policymakers] to use that to build the policy.” More often than not, various governments have rushed plans into action. For example, “Metro Vancouver has made two air quality management plans” that Steyn considers to be made “without  scientific guidance.” Therefore, he “deliberately framed the research in a way that the results could be used for policy…Metro Vancouver has a big process going to understand ozone and what reductions they need to make further.”

Here is a video outlining Dr. Steyn’s study of harmful ozone pollution  and its effects in the Lower Fraser Valley:

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SCIE 300 OUTREACH_SECTION 210_GROUP 2 by kyuuke1013SK

Although we have a clear idea of the present worsening ozone trends, there are still many difficulties, especially emission reductions. Society must strike a balance between the life of convenience that we are accustomed to and the general health of the public. In general Canada manages to  balance things  very well but areas like the Lower Fraser Valley have room for improvement. Our publicly funded healthcare system makes it possible for us to clearly and precisely determine what the cost of degraded air quality is compared to the cost of improving air quality in areas such as Fraser Valley; and we know that the cost of cleanup is a great deal cheaper than the health care costs.

This model is a tool that can be used by researchers and policy makers to increase our understanding of what must be done to ensure the best air quality possible. The health problems that arise from pollutants such as ozone must be avoided at all costs. Progress towards this goal has been made, but there is still much more that needs to be done before we can take a deep sigh of relief!

– Alex Gibson, Stella Meng, Earvin Remandaban, Christine Wong

 

Motion sickness: A quarrel between the eyes and ears

Have you ever started reading your notes or textbook on the bus ride to school, only to find yourself feeling dizzy and nauseous moments after? Or perhaps you’ve experienced the same set of unsettling symptoms on a plane ride, or on a lovely – or in this case, not-so-lovely – Caribbean cruise. Regardless of where you were, it sounds like you were hit by a bad case of motion sickness, a condition that arises due to changes in our sense of balance and equilibrium. As a result, such a phenomenon can develop from the movements of a car or boat, the turbulence of an airplane, or even from the twirls and loops of a ride at an amusement park.

Teacups

If you’re prone to motion sickness, this ride probably isn’t for you.
By jpesci via Flickr Creative Commons

So what causes motion sickness and why do we experience such discomfort as a result? First of all, motion is detected by the brain via signals sent from the inner ear, the eyes, and various sensory receptors throughout the body, and are therefore coordinated together when we walk or move ourselves consciously.

On the other hand, motion sickness occurs when the eyes and ears send different signals to the brain. In this scenario, the movement that is visually perceived “disagrees” with the movement sensed by a specialized system associated with our inner ear. This system, more so known as the vestibular system, contains the organs responsible for the maintenance of proper balance and orientation. Thus, a disturbance to the inner ear caused by any form of repeated motion can cause a person to experience dizziness, fatigue, and nausea, which is explained in this video by YouTube user Alex Dainis.

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This explains why motion sickness can be experienced while reading in a moving vehicle. While your eyes are fixed on an object that is stationary, your body and inner ear sense movement from the speeding or turning vehicle, causing some sort of disagreement between the two.

The vestibular system constitutes the inner ear.
By Rage via Wikimedia Commons

In many cases, motion sickness will ultimately lead to vomiting. This is because the mismatch of signals sent to the brain by the eyes and inner ear suggests that a neurotoxin was ingested, causing the body to induce vomiting in order to get rid of it.

While around 33% of people are prone to motion sickness under mild conditions, 66% experience it under more extreme conditions. Although it is hard to prevent most cases of motion sickness, this video by YouTube user mayoclinic presents some remedies that can be followed to avoid or lessen its effects. If you are one of the 33% that is easily susceptible to this unnerving condition, perhaps these will help make your next vacation or road trip a little more enjoyable.

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– Clarissa Ngui

What do you know about “humanized mice”?

Ordinarily, doctors wouldn’t have much choice for a 56-year-old patient with advanced colon cancer which is one of the deadliest diagnoses, but to try chemotherapy drugs  one after the other each coming with their own massive side effects or to strike the tumour with a bunch of different chemicals that appeared to be functional in previous cases. But today, doctors have a new brilliant option! And that is to try out potential treatments on mice. Scientists were able to  plant human tumours in mice before; yet, there was no guarantee as to how the mice would metabolically react with the implant. That is, if the mice’s reactions would be in anyway similar to that of humans.

Mouse being injected with chemotherapy drugs, credit: Aaron, from aaronlogan.com/blog

In a new approach by Alice Chen, the Lemelsen-MIT prize winner at the University of Stanford in the U.S, young mice are engineered to lack immune systems and then receive portions of human immune system as transplants. As the mice grow older, they tend to develop a very human-like immune response system which, as a result, reacts to drugs and infectious agents just as human immune system would.

Dale Greiner of the University of Massachusetts Medical School said: “the idea is that you can take human immune systems and put them in a mouse and make them functional, and by doing so you can manipulate them as if you were manipulating little humans without ever putting patients at risk.

Here is a video of Alice Chen explaining how she first invented this method by transplanting human liver cells into humanized mice.

YouTube Preview Image This video is from the youtube username Lemelson MIT

Already using this technique, for many cancer patients, scientists have been able to identify the correct treatment before therapeutically testing the drug on the patient. For instance, scientists at UC Davis of California have been able to develop a new drug delivery system for bladder cancer using humanized mice. In their experiment, mice were specially injected with bladder cancer cells from the patients with the disease and the new treatment method was tried out a dozen times on a number of these mice throughout the project. This way, the most reliable treatment was identified and used on human subjects.

Making Mice More Human, Credit: E. Feliciano, from sceinecenews.org

But this is not the end! Humanized mice are not only useful in cancer treatment, but in studying the effect of infectious agents such as HIV and dengue virus,  and complex diseases such as rheumatoid arthritis  and diabetes. For instance, Doctor Greiner, studies the immune system in hyperglycaemic mice in pursue of a better understanding and therefore cure for type one diabetes which is an autoimmune disease.

Although the day your family doctor will be able to grow a colony of  your personal humanized mice is still years away, this is definitely a revolutionary technique to attempt at fighting diseases that we have yet to cure.

-Ashkan Nasr

 

Technological Advance: Resistance May Be Futile

Are you one of those smart phone users who simply can’t be parted from your phone, or one of those wifi junkies who travel from hotspot to hotspot simply looking for your next fix? Well there may be good news for you, as scientists from Duke University School of Medicine have been working on a way to mind meld humans with technology. That’s right, just like the Borg, you too could become one with machine and share a single consciousness with all of your friends! Okay, well maybe not just yet, but they’re certainly making advances in that direction.

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We are the Borg. Resistance is Futile. You will be assimilated.

Courtesy of ragokin via Youtube

That’s right all you Trekkies, resistance may soon enough be futile, as researchers from Duke have successfully linked a pair of rat brains. Using arrays of microelectrodes, researchers attached the motor cortexes of the two rat brains. This allowed the two rats to transmit and receive tactile and motor information to and from each other at will.

In their experiment, both rats were trained to perform certain tasks based on certain stimulus. The rats were then put into separate testing areas and connected via this brain linkage – one was only given the stimulus and the other was put in the response area. The experimenters ran a number of different tests; from making one rat push certain levers based on what light another was shown, to making one rat believe that it had detected infrared light, when there was no light source present. The results were astounding to researchers, as in their first test, the rats achieved a 70% success rate, which was only just slightly less than the maximum 78% success rate that the researchers had deemed possible. Although the experiments were all different, the results were all significant, showing that the rats were consciously communicating. Furthermore, it appeared that the communication was not a one-way street, but instead that the rats were responding to one another. This was indicated by slight changes in the rats’ brain function and behavior – a behavior believed to be as a result of a mutual and concerted effort.

To put all doubt to rest as well as to test the bounds of the connection, the researchers separated the two rats completely – not just in different testing rooms or different buildings, but on two completely different continents. The rat receiving the stimulus was put in Natal, Brazil and the rat performing the actions was put in Durham, N.C., USA. The connection was established using an Internet connection. Miguel Pais-Vera, PhD, was amazed that even despite the distance and the lag associated with Internet connections, the rats were still able to complete the tasks while maintaining a significant level of success. He continued by saying that this research was promising and that in time “it could be possible the create a workable, network of animal brains distributed in many different locations.”

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If not the Borg, it may be a bit closer to this.

Courtesy of Its me simon, via Flickr Creative Commons

– Brian Kahnamelli

Sleep Deprivation Can Cause Changes in Genes?

A sleeping child (Cr. JarektUploadBot via Wikimedia Commons)

Are you getting enough sleep lately?  You probably know that sleep deprivation is bad for you, but to what extent?  Now, a study showed that a lack of sleep affects the gene mechanisms that control metabolism, sleep and immunity.  Just one week of insufficient sleep can cause changes to over 700 genes!  Yikes!

Before this study was done, scientists linked long-term sleep deprivation with obesity, heart disease and cognitive impairment.  However, the actual molecular mechanisms that led to these effects were not known.

The effects of sleep deprivation (Cr. Mikael Häggström via Wikimedia Commons)

Now, British researchers at Surrey University in England showed that long-term sleep deprivation directly alters gene expression for processes such as immune responses, stress and metabolism.  All of the above mentioned affects have a wide range of negative effects, especially if the health issues last a long time.

In this study, researchers had 26 healthy volunteers (as in, no illnesses), but were deprived of sleep.  They then examined the gene expressions in the volunteers.  The people in the “sleep-deprived” group only had about 6 hours of sleep for 7 days consecutively, while the people in the control group had about 10 hours of sleep.  At the end of the week, participants had their blood RNA samples taken.

Both groups were observed and had many tests taken to determine their cognitive performance during the day.  The participants in the study were also asked how they slept.  Finally, researchers measured levels of the hormone melatonin, which regulates biological rhythm and sleep cycles.

The chemical structure of RNA (Cr. InfoCan via Wikimedia Commons)

RNA analysis of the blood samples showed that activity in 711 genes were decreased or increased from the lack of sleep.  As it turns out, every gene is responsible for the creation of a protein that is important in the body.  And RNA is needed to carry out the message from each gene to create those proteins.  If the amount of RNA changes from its normal levels, then this means that there are now more or less of the messages getting sent to create the proteins.  This can ultimately lead to dramatic changes in the body.

Changes to different genes caused different reactions.  Many of the genes that were affected were involved in maintaining the “biological clock” or the circadian rhythm.  It is what tells us what is supposed to happen in a 24-hour clock.  Other genes were known for their overall gene expression – that is, the lack of sleep will cause harmful changes to the body.  Finally, through the study, it was shown that participants also had bad test results on memory, cognition and attention.

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Here’s a short overview on sleep deprivation and its effects on genes! (via. Youtube user: DNewsChannel)

So, what exactly should we take from all of this?  It’s definitely time to sleep more!

– Maggie Chan