Tag Archives: Alzheimer’s

Caffeine: a misunderstood friend

Every once in a while, some of us need a pick-me-up to make it through a long day. It can come in the form of coffees, teas and even chocolate bars. The common element behind these products is the chemical, caffeine. Often labelled as the bad guy in health industries, caffeine has been through a great deal of scrutiny in the scientific community. In the past, many
caffeine-related myths arose. For example, it was once thought that regular consumption of caffeinated products lead to weak bones and increased risk for heart disease. However, many of these false facts have since then been debunked. In addition to the  amnesty granted to caffeine, many health benefits from its use have been discovered which include improvements in both physical and mental aspects of performance and health and even treatments in Alzheimer’s disease.

A delicious cup of black coffee. By Jon Sullivan via Wikimedia Commons

Caffeine has many applications in the sports and health industries. Many studies have been done which note an improvement in performance in certain sports. Researchers found that caffeine intake boosted the quality of work done in sports requiring power like weightlifting, sports requiring periodic bursts of effort like rugby and tennis, and in sports requiring endurance like running and cycling. These effects were observed from just small doses of caffeine typical of the general public. In addition to the benefits achieved in a sports-setting, caffeine also has use in body composition control. An increase in metabolic rate and fat loss was observed in subjects three hours after caffeine intake. Researchers noted an increase in the total amount of available energy in the form of circulating free fatty acids from predisposed fat stores in the body. This specific property can be used in treating obesity and aiding those individuals looking to lose fat with regular exercise. While caffeine has been found to be extremely useful in achieving  physical well-being, it can also play a role in mental health and function maintenance.

Cyclists in the US Air Force. By U.S. Air Force via Wikimedia Commons

Many energy drinks containing caffeine often state that their product helps temporarily restore mental alertness and wakefulness. This claim has some truth to it as most studies involving caffeine have recently found. Countless studies have found that fatigued individuals performed better on cognitive tasks with the ingestion of caffeine. Although it is widely known for its effects on alertness and attention, it can also aid in learning. In a study done in France, a researcher observed an increase in a specific type of learning when administering human participants with caffeine. Passive learning increased in individuals when they given information to remember operating on the premise that no test would be given afterwards. Furthermore, caffeine has applications in the prevention and treatment of Alzheimer’s disease. In one study, it was discovered that taking
500 mg of caffeine or an equivalent three cups of coffee provided protection against this ailment. In most patients with this disease, aggregations of a compounds called beta amyloids were found in their brains. Caffeine’s primary pharmacological action in the treatment of Alzheimer’s disease is the inhibition of certain enzymes needed for the formation of these beta amyloids which resulted in the reduction in the cognitive decline observed in patients.

A discussion of the therapeutic use of caffeine. (attributed to YouTube user: healthycoffeeupdate)
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Caffeine, when used in moderation, is an extremely useful substance. From increasing physical performance to maintaining mental health, caffeine provides many benefits. So next time a barista at your favorite coffee-house asks you if you want either a regular cup of joe or decaf, I’d personally recommend the former!

-Earvin Remandaban

Let’s Get Ready to Rumble!

Whenever Michael Buffers announces “Let’s get ready to rumble!” I get a tingly feeling at the back of my neck because I know what’s about to go down, two men who have trained for months are about to go to battle in a ring with only some gloves on. Being a boxing fan nothing is more entertaining than seeing a boxer knocking out (KO) his opponent.

Ricardo Dominguez (left) and Rafael Ortiz in the midst of a battle. (ShawnC via Wikimedia)

But I never thought of the implications the boxers face, until I saw the debilitating state of one of the greatest boxers ever to live, Muhammad Ali. At the age of 42, in 1984 Ali was diagnosed with Parkinson’s disease, doctors and scientists believe that the main culprit for the disease was possibly the repeated blows to the head he received during his reign in the ring.

Finding studies on this matter was not too difficult, it seems in the recent years it has been a field of intensive study.

“A knock-out in neuro-psychiatric terms corresponds to a cerebral concussion.”

In 2010, a study out of the Technical University of Munich conducted by Hans Forstl evaluated the health of boxers for the past 10 years. They discovered that getting knocked out resulted in persistent symptoms such as headaches, impaired hearing, nausea, unstable gait, and forgetfulness. A long career in boxing may result in boxer’s dementia (dementia pugilistica), which is strikingly similar to Alzheimer’s disease.

So what exactly happens to cause a knock-out?

A report by Popular Mechanics written by Marita Vera goes into technical aspect of the knock-out.

The body contains dissolved sodium, potassium and calcium, collectively known as electrolytes, which are responsible for conducting impulses along neurons. Every time a fighter receives a blow to a nerve, potassium leaves the cell and calcium rushes in, destabilizing the electrolyte balance, while the brain does all it can to keep these levels in balance. With each successive blow, this balance becomes harder and harder to maintain, and more and more energy must be spent in the process. When the body reaches the point where the damage outweighs the body’s ability to repair itself, the brain shuts down, to conserve enough energy to fix the injured neurons at a later point.”

Dr. Charles Bernick and his colleges from the Cleveland Clinic’s Lou Ruvo Center for Brain Health have compiled over a 100 boxers and mixed martial artists (MMA) fighters to conduct studies on their brain. Through M.R.I scans, they found a reduction in the size in the hippocampus and thalamus of the brains of fighter with more than six years in the ring. Dr. Bernick notes that “these parts of the brain deals with the function of memory and alertness.”

This video shows the work of Dr. Charles Bernick:

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Prevention?

Along with Dr. Bernick’s work, Sanna Neselius and her team out of Gothenburg, Sweden are working on bio-markers in the blood that indicates the severity of damage to ones brain.

“Preferably, we would like to find a simple blood test that provides the same information as our more advanced brain fluid examinations. The capability does not presently exist, but can perhaps become an option in the future with further and more extensive studies.”

Discovering what these boxers have put on the line, day in and day out has gained a great sense of respect from my part, hopefully through the power of science there will be better ways to prevent and protect these courageous men and women doing their jobs, while not taking anything away from the true essence of boxing.

-Alvinesh Singh