Tag Archives: mental health

Let’s Get Ready to Rumble!

Whenever Michael Buffers announces “Let’s get ready to rumble!” I get a tingly feeling at the back of my neck because I know what’s about to go down, two men who have trained for months are about to go to battle in a ring with only some gloves on. Being a boxing fan nothing is more entertaining than seeing a boxer knocking out (KO) his opponent.

Ricardo Dominguez (left) and Rafael Ortiz in the midst of a battle. (ShawnC via Wikimedia)

But I never thought of the implications the boxers face, until I saw the debilitating state of one of the greatest boxers ever to live, Muhammad Ali. At the age of 42, in 1984 Ali was diagnosed with Parkinson’s disease, doctors and scientists believe that the main culprit for the disease was possibly the repeated blows to the head he received during his reign in the ring.

Finding studies on this matter was not too difficult, it seems in the recent years it has been a field of intensive study.

“A knock-out in neuro-psychiatric terms corresponds to a cerebral concussion.”

In 2010, a study out of the Technical University of Munich conducted by Hans Forstl evaluated the health of boxers for the past 10 years. They discovered that getting knocked out resulted in persistent symptoms such as headaches, impaired hearing, nausea, unstable gait, and forgetfulness. A long career in boxing may result in boxer’s dementia (dementia pugilistica), which is strikingly similar to Alzheimer’s disease.

So what exactly happens to cause a knock-out?

A report by Popular Mechanics written by Marita Vera goes into technical aspect of the knock-out.

The body contains dissolved sodium, potassium and calcium, collectively known as electrolytes, which are responsible for conducting impulses along neurons. Every time a fighter receives a blow to a nerve, potassium leaves the cell and calcium rushes in, destabilizing the electrolyte balance, while the brain does all it can to keep these levels in balance. With each successive blow, this balance becomes harder and harder to maintain, and more and more energy must be spent in the process. When the body reaches the point where the damage outweighs the body’s ability to repair itself, the brain shuts down, to conserve enough energy to fix the injured neurons at a later point.”

Dr. Charles Bernick and his colleges from the Cleveland Clinic’s Lou Ruvo Center for Brain Health have compiled over a 100 boxers and mixed martial artists (MMA) fighters to conduct studies on their brain. Through M.R.I scans, they found a reduction in the size in the hippocampus and thalamus of the brains of fighter with more than six years in the ring. Dr. Bernick notes that “these parts of the brain deals with the function of memory and alertness.”

This video shows the work of Dr. Charles Bernick:

YouTube Preview Image

 

Prevention?

Along with Dr. Bernick’s work, Sanna Neselius and her team out of Gothenburg, Sweden are working on bio-markers in the blood that indicates the severity of damage to ones brain.

“Preferably, we would like to find a simple blood test that provides the same information as our more advanced brain fluid examinations. The capability does not presently exist, but can perhaps become an option in the future with further and more extensive studies.”

Discovering what these boxers have put on the line, day in and day out has gained a great sense of respect from my part, hopefully through the power of science there will be better ways to prevent and protect these courageous men and women doing their jobs, while not taking anything away from the true essence of boxing.

-Alvinesh Singh

Schizophrenia and the Biological Factors That Contribute To It

 

Do you know that voice you hear in your head? The one you hear when you read? Or the one that has conversations of its own? We all have it. But now imagine that this voice isn’t your voice anymore. This voice has a life of its own. It tells you things you never thought of; it makes you believe that the people and the places you know are figments of your imagination; it makes you go crazy. This is the harsh reality of many schizophrenics.

A lot of us may have heard about schizophrenia, and a lot of us may know of it as simply meaning you’re crazy. The fancy definition of it is a “profound disruption of basic psychological processes.” Your reality is distorted; your thoughts and your behavior are disturbed. Symptoms of this include hallucination, disorganized speech, and catatonic behavior to name a few.

So how do you get it? Will a schizophrenic’s sneeze render you “crazy” as well? Well, no. As many of you may have guessed already, schizophrenia’s origins lie in biological factors, which include genetic factors, biochemical factors, and neuroanatomy.

Evidence for this conclusion lies in studies that show that the closer you are, biologically of course, in relationship to a person diagnosed with schizophrenia, the more likely you are to also develop the disorder. Furthermore, and this is perhaps some of the strongest proof, studies show that concordance rates are higher for identical twins in comparison to fraternal twins. This clearly shows us that genetics play a crucial role in the development of the disorder.

Neuroanatomy, in addition to genetics, is another biological factor that aids in the development of schizophrenia. With the help of neuroimaging techniques, researchers began to look for anatomical differences in people with the disorder. Early observations led them to discover the enlargements of ventricles – hollow areas lying deep within the core of the brain. The abnormal enlargement in some patients suggested a loss of brain tissue mass that could have occurred during prenatal development. However, this evidence is complicated and unreliable for many reasons. First, enlarged ventricles are only found in a few patients. Second, some individuals without the disorder are also found to have enlarged ventricles. Lastly, the enlargement of the ventricles can be caused by some types of antipsychotic drugs, prescribed for the treatment of schizophrenia. Neuroimaging studies provide evidence of a variety of brain abnormalities in schizophrenia. A variety of specific brain changes found in other studies suggest a clear relationship between biological changes in the brain and the progression of schizophrenia.

 

 

The neuroanatomy of schizophrenics differs from those that do not.
Photo Researchers, Inc.

In addition to biological factors, the third factor that contributes to the development of schizophrenia is the presence of excessive dopamine – this is known to be the  the dopamine hypothesis. The hypothesis explains why amphetamines, which increase dopamine levels, often aggravate the symptoms (Iverson, 2006). However, there is evidence that refutes this hypothesis, as many individuals do no respond well to dopamine blocking drugs. All in all, the accurate involvement of neurotransmitters in schizophrenia is yet to be determined.

This link discusses the dopamine hypothesis in detail while interviewing a patient

YouTube Preview Image by itswhatson

Research on schizophrenia and its cure continue today, in the 21st century. While we have made great progress, a lot remains to be discovered about this order that affects almost 51 million people in our world at one time. 

Harleen Kalra