Category Archives: Biological Sciences

The Vegan Movement: Should we really stop eating red meat?

Veganism is growing rapidly amongst the current generation, whether perpetuated by scientific reasoning or simply through social media. Do we truly know what to believe anymore or which diets are the best for us? One popular belief that has upset many meat-lovers is that the consumption of red meat increases the risk of cardiovascular disease (CVD). The main reason is the reaction between a component of the red meat and natural bacteria found in our stomachs.

Steak; everyone’s favourite red meat! Source: Google Images

L-carnitine is an amino acid found naturally in the human body and is also abundant in all the delicious red meats that we eat such as lamb, beef and pork. On its own, L-carnitine helps the body produce energy by facilitating heart and brain functions, as well as muscle movement. However, this study shows that when the digested amino acid is broken down by the natural bacteria in our stomachs, a harmful chemical compound called trimethylamine N-oxide (TMAO) is produced.

TMAO found in blood was shown to result in atherosclerosis, more commonly known as ‘clogged arteries’. Immune cells that exist in the arteries build up cholesterol more significantly in the presence of TMAO. In addition, the study showed that arteries that were exposed to more L-carnitine became more efficient at producing TMAO. Based on their experiments, vegans and vegetarians who were less exposed to the amino acid were shown to convert at a much slower pace.

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So what does this mean for all the meat-eaters? Is this enough evidence to prove that we should completely stop indulging in these sinful dishes? Perhaps turn vegan? An underlying issue is how frequently we consume red meat. Studies have enough support to show that people who eat more red meat have higher risks of CVD, however, the actual amount of consumption to warrant these consequences is still unclear. Just like with any other unhealthy foods, finding a balanced diet will help you avoid problems. Moderation is key!

  • Siriwat Chhem, January 18th 2016

 

Is it safe to eat raw mushrooms?

raw mushrooms

Raw Mushroom Salad Credit: veganarchitect.com

Have you ever thought that eating raw mushrooms is bad for health? I have heard many well known doctors say that raw mushrooms contain toxic compounds that are destroyed by cooking. I used to eat raw mushrooms at the salad bar, but after realizing the toxic potential of them, I try to avoid eating them raw.

WHAT IS HARMFUL ABOUT EATING RAW MUSHROOMS?

To answer this question, we should start off by asking what substances make raw mushrooms toxic. Raw mushrooms have this chemical substance called aragonite, which in large amounts has the potential to cause DNA damage. Aragonite is only broken down by heat, so experts suggest that people should cook their mushrooms.

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IS COOKING ALWAYS NECESSARY WHEN EATING MUSHROOMS?

Directly speaking, I would say that cooking mushrooms is not always necessary. I agree with experts who say since raw mushrooms contain aragonite that can cause DNA deformation, people should destroy it by heat before eating them. However, a team of Swiss researchers argues that the chance that aragonite will cause cancer is minor, so people should not worry too much about getting cancer after eating raw mushrooms.  Moreover, raw mushrooms contain lots of cancer preventive substances, so even if you eat raw mushrooms, you are consuming more healthful substances than harmful substances. It is totally up to the person whether he or she eats raw mushrooms or not, but if I were you, I would not always choose to eat them raw.

toxic mushrooms

Types Of Poisonous Mushrooms With White Or Cream Spores: Credit: hubspages.com

Dohoon Kim

Sperms join the racetrack- Team Spermbot!

Humans are made to be fertile so that they can reproduce. However, many couples cannot have have children for various reasons, the main one being the inability of the sperm to reach the egg successfully. To aid fertility problems there are many pricy alternative fertility options but these have a very low success rate.

In order for a man and women to conceive, male sperm must swim down the female fallopian tubes and connect with the egg. However, some males have difficulties getting their little guys to make it all the way to the finish line. The sperm are usually fully fertile but have difficulties swimming. This is one of the leading problems of male infertility. To resolve this problem, a team of German researchers have invented the “spermbot“.

As published in Nano Letters, the spermbot is a tiny spiral metal helices that rotates and fits around the tail of the sperm. It is big enough to fit the tail but not too big that it goes over the head. The helix can be controlled using magnetic fields. The main purpose of this spermbot is to provide better motility to the sperm so they can reach the egg.

The Spermbot

The spermbot overview. Credit: American Chemical Society

The spermbot works in 4 steps: First, the hybrid micrometer is coupled with the sperm as coupling is the most efficient way for the microhelix to attach to the sperm without killing it. Second, the spermbot starts propelling it to where it to its destination. Third, it makes contact within the ovaries, which is where female reproduction takes place. Once this is completed the final step includes the release of the sperm from the spermbot. This 4 step process was shown to be a success by the German researchers in a petri dish. The petri dish was designed to mimic actual conditions the sperm would face inside a female’s body. This simple yet unique and innovative design could be life-changing for many infertile males as well as their spouses.

The following video gives an overview of the description of the spermbot and how it works.

 

Credit: American Chemical Society

The spermbot is on the brink of being an absolute genius invention, however it needs to be fully tested and all precautions need to be taken before it is put to use in humans. The spermbot could provide various risks for both males and females. The spermbot can be compared to artificial insemination, which is the only fertility option that deals with motility problems. Artificial insemination has a 30% success rate. Whereas the spermbot has a much higher chance of producing a better success rate because of its innovative design and the ability to control it through magnetics. Furthermore, artificial insemination is very invasive for hormonal females, whereas the spermbot provides a non-invasive entry in males. The risks of the spermbot can be controlled once they are identified, and once the risks are eliminated, the spermbot will thrive in the world of fertility.

 

 

Vanessa Sidhu

Do Chimpanzees Trust Their Friends?

Have you ever played a game of “trust fall”? Perhaps you were nervous as those behind you may not have been close friends. Trust is the cornerstone of a civilized society; one in which we can confidently rely on others to uphold their duties in maintaining mutually beneficial relationships.

Conversely,  self interest may cause individuals to disregard their moral obligations to others and use trust as a tool to get ahead. For this reason humans tend to put their trust in friends before strangers as to minimize their risk of danger – but what about animals?

Researchers from the Max Planck Institute for Evolutionary Anthropology in Germany wanted to know if Chimpanzees operated on the same principles. In their previous study, the researchers had acknowledged certain behaviors among the chimpanzees that were similar to human friendships.

If they could show that chimpanzees are selective with their trust, it may imply that trust, and other complex psychological behaviours have evolved from our common ancestors!

To put their theory to the test, Esther Hermann and Jan Engelmann conducted a study, observing closely fifteen chimpanzees from the Sweetwaters Sanctuary in Kenya, where most of them have been living for nearly twenty five years. They began by monitoring the interactions of smaller groups and even pairs of chimps during feeding and grooming times to determine which could be considered friends.

The experiment was set up in a way that would observe whether a chimpanzee would chose a low risk and relatively small reward option over a higher risk and greater reward option. Specifically, the experiment, which was replicated 12 times with both the chimp’s close ally and a stranger, looked like the following:

Two chimpanzees, A and B, are placed in separate rooms joined by a feeding mechanism that includes two ropes: a non-trust rope and a trust rope. The non-trust rope, if pulled, provides the chimpanzee that pulls it with an immediate but not preferred food. The trust rope, if pulled by chimpanzee A, will give chimpanzee B access to a more preferred food first who must then pull the same rope to send the food back to chimpanzee A. Chimpanzee A, in pulling the trust rope, must trust that chimpanzee B will send the food back in order for the event to be mutually beneficial.

The results of the test showed that the chimpanzees preferred the riskier option significantly more when the receiving chimp was a friend. These findings show that the trusting behaviors of humans towards their friends are not solely demonstrated by our species and had perhaps evolved from our predecessors!

The door is open for scientists to explore whether other human psychological behaviours are also being demonstrated in the animal kingdom.

Post by:  Johnny Lazazzera

Type II Diabetes? There May be a Cure for That

How many times have we passed up a delicious sugary treat because we know that it’s unhealthy for us? It just so happens that scientists may have discovered everyone’s favourite new enzyme: glycerol 3-phosphate phosphatase (G3PP).

white chocolate cake with raspberry cream filling and white chocolate buttercream

– Image Source: Sharyn Morrow, Flickr

A recent study by scientists at the University of Montreal Hospital Research Centre discovered that the mammalian enzyme, G3PP, played a crucial role in controlling sugar accumulation in the body and certain fat conversion processes. They observed that G3PP was expressed at various levels in different tissues and that in the presence of this enzyme, there was lower body weight gain and higher levels of high-density lipoprotein which may protect against heart attacks and strokes.

The new discovery of the G3PP enzyme could also lead to promising therapeutic treatments of obesity and type II diabetes. Type II diabetes is a disease in which specific cells of the pancreas have been presented with excess glucose, and over time, insulin secreted from these cells loses its function on other cells throughout the body or they do not react to insulin properly. This results in high blood glucose levels that can affect other organs of the body and lead to serious complications such as kidney failure. Since the G3PP enzyme prevents excess production of glucose and is able to detoxify excess sugar from cells, it could play a major role in treating type II diabetes.

credit: Animated Diabetes Patient

According to the Government of Canada, there are approximately 60,000 new cases of type II diabetes yearly. Factors that minimize your risk of type II diabetes include limiting fat and sugar intake, as well as keeping cholesterol and blood fats within a target level.

It’s still too early to say whether or not G3PP will be an effective treatment for the reduction of type II diabetes, cardiovascular disease, and obesity. Although researchers are optimistic that the G3PP enzyme will reduce the risk of people acquiring type II diabetes, more experimentation with the G3PP enzyme will need to be done before we can determine whether it will be an effective treatment in the future.

– Brian Infanti

Biocatalysts for the production of hydrogen fuel

Hydrogen fuel cells can be used to provide electricity for numerous applications, such as electric motors. They are conceptually similar to batteries, but the contents are not self-contained. A supply of hydrogen gas and molecular oxygen is needed to produce electricity. These cells have several advantages, for example, they are non-polluting, low maintenance, silent, safe and have a high energy efficiency in comparison to gas engines. However, the majority of hydrogen gas is produced from petroleum cracking and reforming reactions. Thus, finding alternatives to generate hydrogen gas, without depending on petroleum is crucial. Existing alternative processes or technologies that generate hydrogen gas include photoelectrochemical cells, electrolysis of sodium chloride and gasification.

Hydrogen fuel cell: How it works Source: Wikimedia Commons

In an article published by Nature Chemistry, scientists from Indiana University have created an efficient biomaterial that catalyzes the production of hydrogen. In the study, the [NiFe]-hydrogenases from the bacteria E.Coli were used as the target for the hydrogen-producing catalysts due to their oxygen-tolerant nature and ability to be incorporated into biomaterials. Hydrogenases are enzymes that catalyze the reduction of protons to form hydrogen gas. The hydrogenase enzyme of E.Coli is encoded in a six-gene operon (a unit regulating the expression of the protein), of which the first two genes, hyaA and hyaB encode for the small and large subunits of the enzyme, respectively. One plasmid (circular DNA strand of a bacterium) was engineered to contain the two genes of the hydrogenase enzyme, hyaA and hyaB, both fused to a scaffold protein. On a separate plasmid, the coat protein gene was present with a different promotor. The scientists induced expression of the hyaA and hyaB genes and expression of the coat protein gene followed resulting in the self-assembly of a shell surrounding the matured hydrogenase enzyme.

The ‘viral shell’. Source: Wikimedia Commons

The viral shell was shown to provide protection from protease (an enzyme that breaks down proteins), thermal denaturation and air exposure. The encapsulated hydrogenase enzyme is 100 times more active than the free enzyme and the coat protein offers protection to its cargo. Utilizing the enzyme’s remarkable capability to produce hydrogen gas, paired with the virus’ ability to self-assemble has resulted in a renewable, efficient and environmentally friendly biomaterial that could be utilized as an alternative fuel source in the future.

As mentioned, roughly 95% of hydrogen gas is generated from fossil fuels and the other 5% is generated from alternative processes. The conclusion of this research is indeed exciting and offers another potential alternative aimed to decrease our dependence on fossil fuels for hydrogen gas production. Hopefully, this process could reduce the operation costs of hydrogen fuel cells, given that conventional methods rely on using complex and expensive infrastructure for the production of hydrogen gas. It is uncertain however, how or if this process will be used to produce hydrogen gas on an industrial scale, given that the article does not mention how much hydrogen gas is produced from these nano-catalysts. The leading professor of the study, says the next step is to “[incorporate] this material into a solar-powered system”.

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Video by: Gregor Scott