Organisms Inside Us

Have you ever wondered how many micro organisms are living inside us? Micro organisms are living organisms that cannot be seen with our naked eyes. They may be multicellular (made out of more than one cell) or unicellular (made out of one cell). Our human body is packed with trillions of microbes (or micro organisms). In fact, our own body cells are out numbered with a ratio of 1:10. So, we are technically 90% germs and 10% human. Microbes are found in all parts of our body in different proportions. Our lung has approximately 1000x less microbes than our mouth and has approximately 1 billion times less microbes than our intestines. Although most microbes are harmless to us, some may cause bacterial infections in humans.

The Human Body = 90% Germs + 10% Human

Top three functions microbes in our body:

  1. Defense mechanism: Microbes in our lungs, intestines and our skin provide the first line of defense against harmful bacteria that enters our body. Good microbes found in these areas play an essential role in preventing the spread of harmful microbes by occupying space so less space are available for harmful microbes to settle down inside us. Thus, preventing us from bacterial infections that may cause fever, diarrhea or other problems. Other than that, researchers have found evidence that microbes that live inside us help promote our immune system cells to grow and replicate.
  2. Keeping us in shape: The trillions of microbe colonies in our intestines help digest fats and carbohydrates, facilitating the absorption of nutrients in cells. Our intestinal microbes also ferment food that we consume. The fermentation process produces chemicals that speeds up our metabolic processes. As a result, the microbes in our gut helps us keep in shape by increasing our metabolism.
  3. Detoxifies us: Microbes living in us are also capable of digesting toxins that we accidently ingest into less harmful substances. Therefore, preventing us from being poisoned. For example, the microbe Lacrobacillus probiotics found in food help the human body detoxify heavy toxic metals such as aluminum.

Good microbes that keep us healthy

Where do we get microbes that live in our body? Most of our microbes that inhabit our intestines comes from the food we ingest. Our skin and lung microbes come from the air we are exposed to. Recently, researchers discovered that newborn infants get their microbes from their mother’s breast milk and vagina. Researchers found that the method of delivery may have an effect on the diversity of intestinal microbes in newborns. They discovered that infants born vaginally and infants born by caesarean section have different intestinal microbe composition. This indicates that we start to develop our microbe colonies from the day we were born.

Microbes inside our body

From Sugar to Morphine

Morphine is an opiate (derived from opium) painkiller, one commonly prescribed for chronic (long-term) and acute (short-term) pain. The current process for making morphine is very extensive and requires farming opium poppies for their poppy straws, from which the morphine is isolated. Morphine is on the Model List of Essential Medicines, formed by the World Health Organization (WHO), which comprise the most important medications for a basic health-care system. Morphine is also used to make other opioids such as oxycodone and methadone.

Image of the opium poppy. Via Wikimedia Commons

Image of the opium poppy. Via Wikimedia Commons

Escherichia coli (E. coli) is a bacterium commonly known for causing food poisoning. Although some E. coli are beneficial and live in our gut, there are many that can cause infections. As the energy-producing processes of these bacteria were similar to the processes involved in making opiates such as morphine, a team of researchers wondered if they could use E. coli to convert sugar into painkillers.

The study, which was published in Nature Communications, was centered around using E. coli to create a precursor to morphine known as thebaine. A precursor is a substance that is used to produce the next substance; thus, thebaine is used to produce morphine. The researchers accomplished this by using four engineered strains of E. coli.

Image of E. coli. Via Wikimedia Commons.

Image of E. coli. Via Wikimedia Commons.

This research has significant implications because of the time it currently takes to produce painkillers. Many poor countries have limited access to opioids, or no access at all. Other production techniques, such as using genetically engineered yeast to produce painkillers, are not efficient enough to challenge tradition opium poppy farming. By using E. coli, the researchers were able to produce 300 times more of the opioid precursor. Another benefit in using bacteria for the production of opioids is that it would only require simple sugars, such as glucose. The yeast production method also faced ethical issues, as anyone that had access to the yeast strain could produce the opioids, leading to the production of street drugs. The E. coli method does not face this problem as the bacteria are difficult to manage and require expert handling.

Image showing heroin, a common street drug. Via Wikimedia Commons.

Image showing heroin, a common street drug. Via Wikimedia Commons.

Once the technique has improved further to increase its efficiency and passed all pharmaceutical regulations, the manufacturing of opioids from bacteria could help solve the deficit in painkillers that the world faces.

Kush Khanna

Wind and Sun are key to end Africa’s Energy Poverty

Energy poverty and the problems with accessibility that many developing countries have is a problem of the 21st century, whether it be affordability by the average person, to excessive time spent collecting fuels to meet basic needs, to the cleanest types of energy available.

 

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This article highlights the major issue of energy poverty in Africa and the possibilities that wind and solar power have to help alleviate the problem. It is scientifically relevant as these types of technologies are being developed and progressing, and we already see more investment in renewable energy sources in developing countries than developed countries.

Wind and solar power have already become the cheapest option for new power generation projects in South Africa. Finance and costs play a major role in decisions to build new projects. Therefore, there is great potential in the developments being made. Wind and solar projects carry lower risks than hydro and coal. Countries such as Germany have successfully integrated these renewable energy challenges, offering a promise to the doubts that Africa’s electrical grids cannot handle energy sources such as wind and solar.

The following video describes the most energy efficient countries, and the ones that are doing the best have policies weaning them off the use of fossil fuels.

 

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After reading these articles, I think wind and solar power will be the key to alleviating the energy poverty of Africa in the future. As they become cheaper options and the technology improves, more financial incentives and investments will be made. For such a large continent, there is tremendous potential by combining renewable energy with a energy poverty ending agenda.

Combination Treatment of Agressive Brain Cancer

Can cancer get any worse when someone tells you the treatment you are given might be recurrent?

Radiotherapy is a type of therapy that is used to treat cancer patients by using high energy radiation to control and kill cancer cells. The high energy radiation used in radiotherapy permanently damages the DNA of cancer cells while the surrounding cells suffer temporary DNA damage in which they eventually repair themselves. The following video shows how a radiotherapy is performed on brain tumor patients. YouTube Preview Image

It isn’t surprising to know that cancer cells are able to repair themselves after a full treatment of radiotherapy on brain tumors. After all, cancer cells can live on! Studies have shown the high percentage of relapse after having brain tumor radiotherapy treatment. 8 out of the 12 patients that had radiation therapy had recurrent glioblastoma while the rest of the patients had recurrent anaplastic astrocytoma, another form of agressive brain cancer.

But thanks to combination therapy, a type of therapy involving both radiotherapy and a drug. This drug or targeting agent, known as Panobinostat makes initial and repeated radiation much more effective, and is currently being tested in a variety of other cancers. It is a histone deacetylase inhibitor that modifies gene expression of about eight percent of RNA molecules produced from genes. This allows changes in protein production, which can unsettle the growth of cancer. The highest dose was tested in patients and was well-tolerated along with improvement in survival.

Combination therapy for brain tumor sounds pretty promising. The next step is to validate it in more and future studies.

Posted on Februrary 28, 2016 by Lorraine Yu

Drill-Free Dentistry, A Solution To Everyone’s Dental Nightmare?

Source: Wikipedia Commons

Anatomy of Tooth
Source: Wikipedia Commons

Going to the dentist can be an anxiety filled rollercoaster for certain individuals. The sounds of drills, the feeling of dental instruments scraping away at your teeth, and constantly having your dentist asking you to “open wider” makes some people think twice before booking their appointment. Cavities, medically known as Caries, are the most common chronic disease in children and arguably one of the strongest reasons why people book appointments to see their dentist in the first place. Cavities are caused by the food remnants left behind after a meal that are combined with acid made by the bacteria in our mouth. This mixture combined with your saliva forms plaque, which will eat away at the enamel of your teeth, causing cavities. Currently, the only solution is to go to the dentist and get the cavity filled. Recently, a study conducted by researchers from the University of Sydney provides a new cavity prevention system that contrasts current dental practices. Caries Management System (CMS) can stop, prevent, and reverse cavities so you won’t need to always get “drilled and filled” every time the dentist sees minor tooth decay.

Before getting into the CMS lets take a look at the current “drill and fill” method used in dental practices so a comparison can be made with CMS. Traditionally, the dentist would start by administering an anesthetic to numb the area around the damaged tooth. Next the dentist would proceed to clean the bacteria filled area via drill, etch the hole, patch it with a dental filling, then remove any excess substance used. The video below by DentalEdu provides an in-depth visual representation of the current process.

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Credit: DentalEdu

Contrasting the current “drill and fill” method of handling cavities, researchers at the University of Sydney found a preventative procedure that found to decrease the need of  fillings by 30%-50%. The researchers conducted their study over seven years at 22 different clinics, with 12 of those using the CMS procedure. The patient-specific procedure consists broadly of:

1. Application of high concentration fluoride varnish by dentists to the sites of early decay

2. Attention to home tooth brushing skills

3. Restriction of between-meal snacks and beverages containing added sugar

4. Risk-specific monitoring. (higher risk patients will have more tailored program to fit their needs)

By using CMS, dental practitioners could change their outlook on how tooth decay is viewed, and patients could have a different perspective on the fearful stigma of going to the dentist. Rather than simply drilling the tooth immediately to rid of tooth decay, as well as taking away the tooth itself, this patient-tailored program focuses more on pre-cavity prevention solutions rather than post-cavity drilling. CMS could change how an average person would view going to the dentist, by knowing that they are going to get personalized prevention treatment rather than a drill at the earliest sign of tooth decay would help people improve their oral health as well as become more educated about it.

Harsh Bhatt

 

 

 

 

 

Krokodil: A Drug That Literally Turns You Into A Zombie

Warning: there are graphic images in this blog post.

While drug usage and addiction has been a problem throughout history, drugs have not always been the easiest vice to access. This may be due to barriers such as strict drug control rules in countries or simply, the drug in question being extremely pricey. However, what if a drug that is relatively unknown and yet sold at lower prices relative to its counterparts suddenly emerged?

Enter Desomorphine, or more commonly known by it’s street name, Krokodil. Despite being around in Siberia since 2002, it only recently hit the shores of North America. This little known drug is an alternative to heroin and is derived from morphineSimilar to other hard drugs, it is highly addictive.

Gangrene

Gangrene is just one of the few deadly effects of Krokodil usage.

However, what sets Krokodil apart from the pack is its deadly effects. Research has found that injecting Krokodil could cause severe damage to the body. Liver and kidney damage as well as rotting gums and bone infection are common problems; with necrosis, gangrene and blood poisoning as icing on top of this very deadly cake. Continued injection of Krokodil could cause a problematic build-up of gangrene  which would lead to amputations or even, a loss of life. 

Of course, Krokodil would not be such a  big problem if it was harder to access compared to other hard drugs. Unfortunately, this is just the opposite. In a recent news site, it was reported that Krokodil prices in Russia go for as low as 5 euros; this, being 10 times lower than Heroin which gooes for aroound 50 euros. With this absurdly low price barriers, many drug addicts who are strapped for cash and need a quick and cheap high could turn to Krokodil as an alternative. It is important that the deadly effects of Krokodil be highlighted so that action can be taken to combat the usage of this drug and people can be educated about the severe risks that lie in its usage. 

A drug that gives a high similar to heroin but at a fraction of the price? To an addict this may sound like the ideal alternative but many fail to read the fine print; another price to pay for their high is to be slowly turned into a rotting pile of flesh. A zombie.

The video below helps to give insight on the lives of Krokodil addicts.

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Credit: Time on Youtube

Vanadium. Can it replace insulin and cure diabetes?

Vanadium (V) is a chemical element located in the d-block of the periodic table as part of the transition metals. Vanadium exists as a trace metal in both plants and animals and vastly abundant in Earth’s crust and sea water. This Vanadium has become a big issue over past decades as it could possibly replace the usage of insulin as to treat diabetes mellitus (DM).

Image from Wikipedia.

Image from Wikipedia.

Vanadium mimics insulin. Just like insulin, vanadium lowers glucose level in the blood, improves insulin sensitivity and normalizes liver enzyme activities. However, insulin has couple drawbacks as it must be injected as it is a protein and gets digested in our stomachs before our bodies absorb. Unlike insulin, vanadium can be orally taken as metals without getting digested in the stomach and can be readily absorbed through the guts solving the discomfort of injecting insulin.

 

Moreover, vanadium is safe. According to an article, doses of up to 400 mg per day is even in the safe level where the recommended dose for a patient is 100-150 per day. In general, the toxicity of vanadium is very low. A study denote most of the toxic effects of vanadium result from local irritation of the eyes and upper respiratory tract rather than systemic toxicity.

 

Not only vanadium is used for diabetes treatment, but also for cancer and and bone formations. Although clinical data and researches are lacking, laboratory studies on human cells demonstrate that vanadium could help promote apoptosis and suppress the growth of cancerous tumours. Furthermore, tests on animals and human cells suggest that vanadium may promote osteogenesis.

 

We do not completely know the virtue of vanadium due to lacking experiments and testing. But many papers and researches have proved vanadium is safe and efficient which could potentially replace the use of insulin in the future.

 

This is a youtube video of a pharmacist explaining why vanadium is important.YouTube Preview Image

 

Sung Eun Kim

Intimately Entangled – A Quantum Mechanical Love Story

 

Albert Einstein 1879-1955. Wikimedia Commons

Albert Einstein 1879-1955.
Wikimedia Commons

The man of the hour, Albert Einstein, has made quite an impact throughout the history of theoretical physics. Most recently however, the gravitational waves that Einstein’s theory of relativity predicted were detected on September 14, 2015 at 5:51 a.m.

An intelligent man indeed, yet even the brightest minds can be wrong. For instance, this brilliant theoretical physicist was unable to wrap his mind around an idea that arose from the theory of quantum mechanics – quantum entanglement.

'Intimately entangled' giraffes. Pinterest

‘Intimately entangled’ giraffes.
Pinterest

Quantum entanglement is a phenomenon that allows us to know the state of one particle if we measure the state of it’s partner particle. In essence, these two particles remain intimately ‘entangled’. Einstein remained unsatisfied about the notion that these particles were able to determine each others’ fate even at large distances apart. He argued that this “spooky action at a distance” should not be considered a theory as it holds too much uncertainty.

Due to Einstein’s apprehension towards quantum entanglement, John Stewart Bell came up with Bell’s inequality experiments. Bell’s tests showed a correlation between entangled particles which were a distance apart and this correlation was observed “more than a percentage of the time”.

However, 3 loopholes in Bell’s experiment were discovered and could have eradicated the idea of quantum entanglement had they not been closed by today’s scientists. The first loophole points out that all entangled particles are not detected, meaning that the undetected photons could potentially change the statistical results that support quantum entanglement. The second loophole marks the notion that the entangled particles may affect each other’s state before detection by observers. The final loophole states that this idea may not be random at all, and that the observer is actually unable to detect the pattern.

The first two loopholes were closed by Hanson and his team; their experiment used diamonds to observe the state of all the photons which closed the first loophole, as for the closure of the second loophole, the electrons emitting the photons in their experiment were far enough apart that they were not able to communicate before the observer detected their states. A solution to the final loophole is currently in the works attempting to explore the random nature of the detection of photons. A paper submitted by Dr. Lynden Shalm and his team, that has yet to be peer-reviewed, has shown their attempt at using “random number generators and high-speed polarization measurements” to prove the random behavior of the particles.

The following video by Joe Scott found on YouTube indicates how scientists are currently closing loopholes.

Sorry Einstein, but it seems that quantum entanglement is looking pretty feasible thanks to the work done by scientists. They’ve worked on closing Bell’s loopholes and thus provided support for quantum entanglement.

Working with this theory of quantum entanglement, society can look forward to research into more efficient computing. For instance, in 2013 Google and NASA experimented with a computer that runs 108 times faster than a typical PC, and this is just the beginning.

 

                      – Paria Assadipour