Category Archives: Biological Sciences

ACHOO syndrome: not your usual sneeze

Have you ever experienced a desire to sneeze after looking at an abrupt bright light, like the sun? I know I have, along with about a third of the world’s population.

Photo of a man sneezing. Author: James Gathany via Wikimedia Commons

This surreal way of sneezing is called photic sneeze reflex, or, conveniently, ACHOO syndrome. Despite being highly prevalent around the world, we know very little regarding this phenomenon. In fact, a study has found that victims of this reflex, including myself, think this occurs in everyone, whereas “normal” people become bewildered when finding about its existence. This level of unawareness might be due to the little threat that this condition poses to those who have it.

YouTube Preview Image

Due to the common occurrence of this condition within a family, it is generally regarded as an autosomal dominant trait, which simply means that it is likely for an affected parent to have an affected child. This is surprising, since the sneeze that we are all familiar with is acquired from environmental factors like viruses, regardless of how we are genetically shaped.

So how is it then that the sun or any other light sources trigger sneezing? Many theories were considered, with the first one dating back to Aristotle’s time. He speculated that the sun’s heat had a direct effect on the nose, causing it to become irritated and therefore induce sneezing. Clearly, this hypothesis was refuted later on, because the sneeze disappears if you close both eyes.

The most supported reasoning behind this involves the cranial nerves, particularly the optic and the trigeminal nerves. It is our trigeminal nerve that is primarily responsible for sending information that leads to sneezing to the brain. However, due to the complexity and the compactness of our heads, this nerve occasionally picks up signals from other sources, like the optic nerve. Thus, when some of us look at a bright light that stimulates the optic nerve, it is erroneously translated by the brain as the body’s need to sneeze.

Here is a video that gives a very simplified explanation:

YouTube Preview Image

 

As I mentioned before, this condition is generally harmless to those who have it. However, it can still pose serious risks in certain situations. For example, it is common for drivers to get a sudden outburst of sunlight shone onto their eyes. 66% of the population would squint their eyes and pull down the sun visors. The remaining 33% on the other hand, would experience an uncontrollable movement caused by the photic sneeze reflex. Considering that they are driving, you can imagine how dangerous that can be.

Although you may find it hard to believe, there is a perk to inheriting this condition. I am sure that all of us had a moment where we had a desire to sneeze, but was not able to produce it. However, this is not a problem for around 2.3 billion people, including myself, since we can deliberately produce a sneeze. Besides, who wouldn’t want to feel elevated, given that a sneeze is 1/8 of an orgasm?

-Sanggi(Daniel) Hong

The Perfect Nap

Have you ever wondered how long the perfect nap is?  As we are all university students I am sure that at one point or another we have had the urge to take that quick nap in an attempt to replenish our mind and body.  However, I feel that most of us have also experienced waking up from our nap feeling groggy and just plain out-of-it.  So what is the secret to a perfect nap?  It is called the power nap!

Nap time by buhny via Flicker Creative Commons

To understand the power nap we must first understand how the stages of our sleep cycle work.  Essentially, sleep comes in various stages.  In the beginning, known as the light sleep stages, you drift off as your brain slows down.  On the other hand, in later states, known as the deep sleep stages, you reach deep sleep and REM.  When we awake from the earlier stages we feel refreshed, alert and energized! This is because your brain hasn’t fully entered the sleep cycle and so waking up from it isn’t a strain on your brain. But on the other hand, if we awake during the deep sleep cycle we wake up feeling groggy and exhausted.  This is because your brain has now entered deep into the sleep cycle, thus interrupting this cycle makes you feel the opposite of refreshed.

YouTube Preview Image

Youtube by AsapSCIENCE

Now you may be wondering how long of a nap this would require to avoid the deep sleep cycle.  Many studies have shown that power naps less than 30 minutes are ideal for most people in achieving optimal results when waking, as these awake you during the light sleep cycle.  For example, there was a study at the University of Düsseldorf that discovered that even naps as short as 6 to 10 minutes were able to restore memory , alertness and better learning/performance.  Additionally, the Flinders University explained through their study that a 10 minute nap was the best length for a nap in terms of recuperation.  This 10 minute length was based on the subjects only having 5 hours of sleep the night prior.

Idea Man by hank_rhoads via Flickr Creative Commons

Idea Man by hank_rhoads via Flickr Creative Commons

Overall, the power nap can be extremely efficient in dealing with exhaustion and a fatigued mind when done right.  It seems weird that a shorter amount of napping time will lead to better results when waking up, but we must consider how our brain functions when we sleep.  So the next time you get back from lecture and only have an hour or so before your next lecture, why not try out a quick power nap to refresh and replenish your mind and body!

-Derek Rejto

Sci-Fi turned into reality: Transplant organ made from plastic!

A lot of things around us are made of plastic, but did you know that plastic commonly found in soda bottles can be made into a fully functional organ that can be transplanted into patients?

Human organ is one of the most scarce medical resources.  For example, in Canada last year, nearly 5000 Canadians were on waiting list for organ transplant, and about 200 people died while waiting for one. What if YOU needed a transplant organ one day? Wouldn’t it be nice if there were a way to synthesize human organs from scratch? It turns out that stem cell research is the most promising solution to organ shortage.

So what are stem cells? Stem cells are cells that have the ability to self-renew and turn into specialized cells. Examples of stem cells include bone marrow cells and blood cells.

A couple of years ago, a patient named Andemariam Beyene had a tumor in his windpipe and was out of treatment options. His doctor Paolo Macchiarini came up with a radical idea: to build a new windpipe out of plastic and the patient’s own stem cells.

Video about Mr. Beyene’s plastic trachea: 

http://youtu.be/_GyQWAiDu0w

(From youtube user NTDTV)

The tissue engineers first obtained CT scans of the patient’s existing trachea and tailor-made the plastic trachea to ensure it matched precisely.  They then covered the plastic with the patient’s bone marrow stem cells and placed it in a in an incubator.

After two days, the semi-artificial organ was implanted into the patient’s body. The surgery was a success and Mr. Beyene is now breathing normally. In fact, he does not even need to take drugs to prevent organ rejection issues (which are common problems associated with donor organs) because his own cells were used to develop the transplant organ.  

As of today, only simple organs like windpipe have been made from stem cell and transplanted, but the future of stem cell research is promising. It’s possible that in 10 years or so, complex organs built from stem cell will save your life!

-Stella Meng

Why I Wouldn’t Follow Dr. Oz Down the Yellow Brick Road

Dr. Mehmet Oz was educated at Ivy League universities, has won numerous medical awards, is a professor and vice-chair of surgery at Columbia University College of Physicians and Surgeons and came to prominence giving medical advice on the television show Oprah. Sounds highly credible right? On paper yes, but let’s take a closer look.

Photo of Dr.Oz at the Time 100 Gala. Author: David Shankbone, via Wikimedia Commons

First, let’s talk about those “miracle supplements” Dr. Oz so commonly refers to; in particular, Garcinia cambogiaDr. Oz stated that this was “the newest, fastest fat-buster.

YouTube Preview Image

From YouTube user: garciniacambogia009

No exercise, no diet, no effort? It sounds too good to be true, right?  It is.

Slate.com was first to bust this “find” and stated that in 1998 a study looked at its effects as an “antiobesity agent” in 135 people and found that Garcinia cambogia pills were no better than placebo for weight loss. More recently, a study involving 706 participants was unable to provide support that Garcinia cambogia extract had any impact on weight. In some studies, a few trials showed short-term slimming, but the overall effects were so small and most studies were so flawed that the authors were unable to conclude any results. Dr. Oz handpicked data to support his claims because really, who wants to watch a television show exclaiming “Garcinia cambogia: Proven to do nothing!” It seems Dr. Oz has sold his scientific morals for ratings.

Experiencing large disapproval from the scientific community, Dr. Oz decided to conduct his very own experiment to prove he still has his roots firmly planted in the scientific method. Unfortunately, Dr. Oz only managed to add supporting evidence that he does not follow good scientific practices. Looking for toxic levels of arsenic, he tested apple juice from five popular juice makers in the U.S. claiming that he found toxic levels in all five. There are too many problems with this study. First, Dr. Oz asked a lab to test for total arsenic, but there are two forms of arsenic: Organic and inorganic. Organic is found everywhere and is practically harmless. He received a warning letter from the FDA stating that arsenic occurs naturally in many foods and that only inorganic forms are toxic. Testing for total arsenic can therefore not be used to determine whether a food is unsafe. Second, never replicated his own results. He didn’t even question the numbers he got from the lab, which the FDA warned were giving erroneously high results. Yet, Dr. Oz  showed no hesitance when reporting the results on his show. He didn’t express even the slightest uncertainty about his findings. Even the media caught on. ABC’s medical editor interviewed Dr. Oz who danced around the accusations.

YouTube Preview Image

From YouTube user: ABCNews 

These are just a couple instances of Dr. Oz demonstrating a lack of adherence to scientific principles. He may have the brains and the heart for science, but Dr. Oz needs to find his courage as he presents himself as the cowardly lion far too often.

-Nicole Gehring

G-Flux: Formula for a Superior Body Composition

The popularity of fitness training seems to have increased exponentially over the past couple of years or so. Fortunately, this means that people generally are more educated about how to train and eat properly. However, although people are finally realizing that the “less is best” diet is the most effective, many individuals who are mindful of caloric intake and expenditure do not know that there is an association between the level of this energy balance and body composition. Enter John Berardi‘s principle of G-flux.

Balance of energy in the body (Found at: http://www.180degreefitnesssystems.com/images/negative_energy_balance.jpg)

John Berardi argues that a higher energy balance, that is, a higher amount of energy into the body accompanied by higher energy expenditure by the body, is superior for body composition. So how does G-flux work? Take, for example, an individual who does little to no physical activity from week to week. This person’s daily requirement of calories to maintain their current body composition will be low, due to low energy expenditure. If the same individual were to engage in five to seven hours of weekly physical activity, their energy expenditure will be much higher. Provided that the energy taken into the body (food eaten) balances the caloric expenditure, energy balance level or G-flux, will be higher. G-flux says that the net effect of this higher energy balance is a body that not only possesses a superior composition, but performs better, also.

Ultimate couch potatoes. Author: LAIntern, via Wikimedia Commons

VS

Usain Bolt after World Record breaking 100m at Beijing Olympics. Author: Richard Giles, via Wikimedia Commons

Some might ask how the body can produce a better composition while still taking in maintenance levels of calories. Many experienced athletes, fitness buffs and studies will tell you that in order to cut fat, a caloric deficit must be achieved – the amount of calories taken into the body (through food) is less than the calories burned through exercise and other activities. This is a tried and true method for leaning out the body, but in a state of caloric deficit the body builds little to no muscle, and other effects such as fatigue may occur. In a state of high G-flux, however, the body is in an environment where fat loss is promoted through intense and frequent activity while still being able to build muscle at maintenance calories.

A great (and humorous) explanation of G-flux by YouTuber, Omar Isuf.

YouTube Preview Image

How can you increase your G-flux? Simply increase your weekly exercise. Choose physical activities that are relevant to your fitness goals and do them for a minimum of five to seven hours a week, while increasing your food intake accordingly to achieve that higher energy balance.

– Curtis M.

For more information on diet and caloric intake, see Earvin Remandaban’s post.

A Little bit of Science That’s the Bee’s Knees

The human knee is a delicate structure, and those who have played sports or done any activities that are high impact know it better than anyone. They’ve felt the pain during the activity, felt sore for weeks after, and have thought to themselves whether or not the activity was sustainable – whether it would be possible to enjoy it into their old age, or whether instead it would render them immobile for their later years. There is hope though, as a new surgical technique in the works has shown to significantly help with cartilage regeneration.

photo

A model of a knee joint. Holly Anissa via Flickr.

The knee is one the most complex joints in the body, and is the meeting place of the femur, the tibia, and the fibula, and is composed of bone, muscle, ligament, tendon, and cartilage. It contains four ligaments (LCL, PCL, ACL, MCL), responsible for the stabilization of the knee joint, a number of tendons, and two large pieces of cartilage that are responsible for absorbing shock and bearing weight.

YouTube Preview Image

I wonder if he’ll be able to do that again in twenty years?

Courtesy of Teebzguy via Youtube

The prognosis isn’t the best for athletes (both amateur and professional) that participate in a number of popular sports, the highest incidence of knee injury resulting from participation in Football, Skiing, Basketball, Rugby, and Soccer. Although very common injuries include the tearing of the Anterior Cruciate Ligament (ACL) and the Medial Collaterial ligament (MCL), cartilage damage is still a very large concern for both athletes as well as the medical community taking care of such injuries. Due to the strenuous forces associated with these high impact sports, over time, the two large pieces of cartilage in the knee wear down. For some athletes, if left untreated, these pieces of cartilage can wear down completely, until all that is left is bone. When this occurs, simple movements of the knee will result in excruciating pain, as the femur, tibia, and fibula all grind together.

There is good news though! A game changing technique coming out of Johns Hopkins University has proven to lead to significantly higher cartilage regeneration than previously used techniques. Current cartilage repair is undergone by drilling tiny micro holes into surrounding bone, in an attempt to allow the stem cells inside the bones to seep out and form into new cartilage. A study, headed by Blanka Sharma, shows that this old technique led to an average of 64% of the tissue being replaced. The new technique, however, employs the use of a hydrogel along with the drilling, and has shown to lead to an average of 86% of tissue regeneration. Jennifer Elisseeff, Ph.D, along with a number of her co-workers speculated that the old technique was ineffective because it lacked structure for the stem cells to grow on. After years of laboratory testing, the first trial proved a success, MRIs showing there to be no mal-effects associated with the hydrogel implants as well as the increased tissue regeneration.

The technique is still waiting for European approval, and for the time being has been taken over by an independent American company, Biomet. Jennifer Elisseeff, Ph.D has high hopes for the technique, stating that she hopes that “it will become a routine part of care and improve healing”.

Going bananas!

Bunch of bananas by Ian Ransley via Flickr Creative Commons

There are more to bananas than what meets the eye as recent studies have shown that bananas can help fight cancer. Bananas are very nutritious and contain a fair amount of vitamin C, vitamin B6, potassium, as well as dietary fiber. It doesn’t just stop there; it is low in saturated fat, sodium and cholesterol and as the bananas ripens the amount of antitoxins increases.

Banana’s nutritional values via http://nutritiondata.self.com/facts/fruits-and-fruit-juices/1846/2

While most people eat bananas as part of their daily fruit and vegetable intake, bananas are found to be beneficial to the human body. Research have shown that bananas provide health benefits such as relieving morning sickness, lowering blood pressure, increasing nutrient absorption, maintaining a healthy digestive tract — and most surprisingly, it helps prevent cancer.

Take a look below at Dr. Willie T. Ong’s health blog regarding the benefits of bananas.

YouTube Preview Image

From YouTube user: Kindguymd

A type of cancer scientists have associated with bananas is a type of kidney cancer called renal cell carcinoma, also known as hypernephroma. The tumours can travel to other areas of the body if they get into the lymph nodes (a process called metastasis), and the degree of spreading is categorized by the different stages of cancer. A cohort study done by van Dijk et al. explores the relationship between vegetable and fruit consumption and the risk of renal cell carcinoma. Although through their findings they found no association between total vegetable and/or fruit consumption, they did find that bananas have a protective effect. Furthermore, they mention another cohort study that has found statistically significant inverse association between bananas and renal cell carcinoma as well as previous reviews concluding a reduced renal cell carcinoma risk with vegetable and fruit consumption.

And there you have it! Start snacking on those bananas! Maybe next time when you’re eating a banana, you won’t think of it as merely a fruit!

For further readings regarding the studies on bananas and cancer see here.

– Alice Lin

Is Botox Safe?

Effect of Botox (Source: http://www.rejuvmedical.com/pages/BotoxCosmetic/)

Everyday term “Botox” is not the correct term of therapy, but the trade name of Botulinum toxin A, a protein and neurotoxin. Botulinum toxin A is secreted by anaerobic bacteria, called clostridium botulinum. This toxin deters the secretion of acetylcholine from the endings of the motor nerves. The main function of acetylcholine is to transmit a nerve impulse to a muscle, causing it to contract. Thus, the blockage of the neurotransmitter leads to paralysis and relaxation of the applicable muscle. This feature makes the Botox be used widespread for cosmetic use as well as medical use, for it removes wrinkles, and smoothes out facial lines, giving skin a smoother appearance. There has been a controversy whether the Botox is a safe and effective procedure or not because the toxin causes a fatal illness to humans and animals.

Image of how botox works (Source: http://www.odec.ca/projects/2004/tsej4j0/public_html/process2.html)

Generally, some health groups are against the use of Botox to prevent aging. These groups often point out that Botox is made up of commercialized Botulinum toxin A, which is proven to be poisonous and life threatening to organisms. This is indeed true. However, to accurately examine the safety and effectiveness of using Botox, we need to look at how cell biology mechanism of the toxin works. Botulinum toxin type A has both heavy chain and light chain. It uses its heavy chain in order to bind to acceptor sites on motor nerve terminals and enter a neuron through endocytosis. Using the protease activity of the light chain, Botulinum toxin A cleaves and degrades the SNAP-25 protein, which is needed to release neurotransmitters, particularly acetylcholine, from vesicles that are located in the axon endings. This results in the disruption of the release of acetylcholine that transmits a nerve impulse to a muscle, causing it to contract. Consequently, paralysis and relaxation of the applicable muscle happens for about four months.

From the mechanism above, when used in therapeutic dose, Botox does not cause serious and harmful problems to humans. In fact, pharmacological Botulinum toxin A has an excellent safety record. The most common and main side effects of Botulinum toxin A are injection site pain and bruising. Its estimated lethal dose for human beings is within the range of 2500–3000 units. Furthermore, it has been long time since Botox was approved by the FDA. It was first approved by the FDA as treatment for blepharospasm in 1989, and then for dystonia and hyperhidrosis in 2000. Finally, in 2002, Botox was approved as the cosmetic enhancement. The effectiveness of Botulinum toxin A in treating diseases is clearly exhibited by the study done by Carruthers, JA.

In conclusion, the use of Botulinum toxin A in cosmetic facial procedures and medical use is very reliable. It is very safe since typical dosage for cosmetic use is 20-50 units while lethal dose is 2500–3000 units for humans. Use of Botox in a safe and effective manner depends on how patients follow the procedures under authorized health care providers.

YouTube Preview Image

This shows how botox is safe and used in many ways by dermatologist Dr Barry Lycka. (This video is from the youtube username Barry Lycka.)

-Jong Jin Park