The Two “E”s to Avoid Cancer: Exercise and Eat Well

Cancer is a mysterious silent killer whose cure, even to this day, cannot be found.  Many studies have found a link between weight gain and obesity to increased risk of cancer.  Could the solution to cancer prevention be something as simple as getting enough exercise and having a proper diet? As many of you know, the idea of following a healthy diet and exercising regularly is beneficial and we are constantly reminded by our friends, family and even the media. However, unknown to many of us, what we think is a common idea may be very effective in preventing obesity-related cancers.

Healthy Salad by Emilian Robert Vicol via Flickr creative commons

How exactly does being overweight relate to increased cancer risks you ask? Simply put, it has been hypothesized that many hormones or proteins involved in the development and progression of diseases such as cancer, are secreted by adipose tissue. Therefore, the more fat accumulated in the body, the more hormones secreted or “genes” expressed that can take part in the pathways leading to cancer. To examine the effects of weight loss on fat tissue gene expression and subsequently, the amount of hormones secreted, Dr. Kristin Campbell, a researcher at the University of British Columbia, and associates studied the effects of exercise and diet on body fat tissue. 

Dr. Kristin Campbell working with Scenery Slater, a cancer patient by Martin Dee via http://www.publicaffairs.ubc.ca/2012/06/06/blame-it-on-chemo-brain/

Forty-five postmenopausal women participated and were divided into 4 treatment groups: a control group (no treatment), a calorie-restricted diet group, an exercise group and a diet+exercise group. Blood and adipose tissue samples were taken from every participant before and after following the treatments for 6 months. The samples were then analyzed for changes in hormone levels or fat tissue expression in the body. It was found that women who followed only a calorie-restrictive diet lost the most weight and greater weight loss was correlated with greater changes in fat tissue gene expression. In other words, reducing the amount of body fat ultimately reduces the chances of developing diseases such as cancer.

How women were divided into different groups in the experiment

For further details on the motivation of Dr. Campbell as well as the findings of the research, take a look at the video below:

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Youtube via whywontmynamefit

Although the subjects were all postmenopausal women, Dr. Kristin Campbell notes that weight loss can also reduce the risk of colon cancers and other obesity related diseases that affect men and women equally. From the research findings, we can see how important being healthy is for not only older generations, but for the younger generations as well. We hope our blog motivates others to live a healthier lifestyle.

With that being said, listen to the podcast below for Dr. Campbell’s suggestions for exercise and diet regimes:

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– Grace Lam, Alice Lin, Ashkan Nasr, Derek Rejto

Robot Invasion?

With the drastic increase of technology in robotics in the past decade, should we be fearful robots will take our jobs in the future?

Robot apocalypse anyone?
(via Flickr: A.G Photography)

Posdoctoral research fellow Brian Gleeson in the University of British Columbia computer science department doesn’t believe so – his paper “Gestures for Industry” seeks to push the boundaries of human interactions with robots in a society where mass production is essential for satisfying the demand for goods by consumers.

Significant technological advancements in relatively short periods of time have not only resulted in better household goods, but have also extended to the production process itself. The use of robots in every nook and cranny of industrial assembly lines has allowed for faster, more efficient production of goods. However, over the years, the transition to more mechanized labour has come under fire from the human workforce – many fear for the security of their jobs.

This video below shows the progress of technology and robotics, and what this implies for job security:

YouTube Preview Image(Youtube via CurtMattack)

Technological advancements are showing no signs of slowing down, so are robots destined to take over the production process entirely?

Fortunately not, and many will take comfort in learning that the “Gestures for Industry” paper explores the integration of robotic assistants to increase efficiency, safety and to reduce stress on workers.

Dr. Gleeson has extensively studied human-human interactions, as well as human-robot interactions using only hand gestures to accomplish various tasks. Through this, they discovered that participants, human or robot, must know what the task is ahead of time. For example, knowing whether the task is placing a part in a specific location or manipulating multiple parts is imperative to fully understanding their partner’s hand gestures. Just like the human-human teams, the human-robot teams were able to perform these tasks that communicated specific details without any vocal, touch or eye communication. Dr. Gleeson’s research is one of the first stepping-stones towards human-robot interactions and the future implications of these findings are endless.

These are the types of one-armed robots Brian Gleeson and his team work on.
(via Wikimedia: Lionel Allorge)

The podcast below provides insight on Brian Gleeson’s study and delves into the future of robotics.

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While the field of robotics is undoubtedly advancing at a significant rate, human workers need not be concerned with being out of a job. Dr. Gleeson states that robots have already replaced humans in the workforce wherever possible, and that the next step to a safer, more efficient production process requires humans and robots to coexist and cooperate with each other, ultimately resulting in a higher standard of living.

On a side-note, a recent article from Forbes reports robots will actually create more jobs.

– Nicole Gehring, Harleen Kalra, Curtis Ma, Alvinesh Singh

The Seaweed is Always Greener in Another Pond

When you ask a group of people to name Earth’s most important group of organisms you’ll receive a variety of answers. Regardless of whether or not they have a scientific background, you will rarely hear anyone say algae. However, as more and more research accumulates, it is becoming clearer and clearer that the correct answer might just be algae. That’s right, that weird green and red slime that you see at the beach is by far one the most important group of organisms on this planet.

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Courtesy of Arthur Chapman via Flickr Creative Commons

Whether it is green, brown, or red, algae are the most important organisms you have probably never considered before. Consider the following: the breath of fresh oxygen that you’ve been enjoying while reading this sentence, as well as every other breath you have taken in your life, is mostly thanks to oceanic algae. In fact, it is estimated that about 70 – 80% of the oxygen we breathe is a product of algal photosynthesis. This is an astounding figure, especially when most people consider our forests to be our source of O2. And it’s not just oxygen that algae provide humans with.

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Courtesy of Oregon State Parks’ via Flickr Creative Commons

Have you ever enjoyed a nice scoop of ice cream on a hot summer’s day? Have you ever enjoyed a dairy product, or bread, or canned meat? If the answer to any of these is yes, then you might just have to send thanks to algae. Algae are a source of agar, which acts as a thickener, and is an additive in nearly everything, from food to cosmetics. Agar is also irreplaceable in fields of science such as biology and pharmacy where organism growth is a key part of research.

Courtesy of Kate Donkin via Flickr Creative Commons

Algae don’t just provide a medium for biological and health related research – even before the emergence of science, as we know it, Corallinae algae were used for thousands of years as an anti-worm remedy. Nowadays, algae are still used in the healthcare industry. Corallinae, with their structure and calcium content have been found to greatly enhance bone regeneration, extracts from the Dumontiaceae algal family have been shown to inhibit the herpes virus in non-human patients, and Carrageens, which are extracted from red algae, are currently an active ingredient in a number of anti-viral drugs.

Recently, algae have begun to play an even more important role in our lives. With global warming becoming a larger and larger concern, Exxon, BP, and Chevron have started to grow and harvest large quantities of algae for biofuel. Not only does the use of biofuel prevent the environmentally destructive harvest of non-peak oil, but the growth of large amounts of algae also acts to remove a significant amount of C02 from the atmosphere. On a smaller scale, a French scientist has started working on a unique algal lamp. These lamps, using just oxygen, a small internal light source, and photosynthetic algae produce both light and oxygen, consuming only CO2. And the quantity of CO2 is substantial – it is estimated that a single lamp uses 150-200x the amount of CO2 annually that a tree will use in its lifetime.

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Courtesy of shamengo2 via Youtube

Although you wouldn’t usually think twice about them, algae are, in a lot of ways, the cornerstone of life as we know it.

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– Abby Perehudoff, Clarissa Ngui, Brian Kahnamelli, Jong Jin Park

Ozone: Friend or Foe?

Did you know that living in a city with with high levels of air pollution increases your risk of getting lung cancer by 20%? Every year humans are spewing more and more pollution into the Earth’s atmosphere with CO2 attracting the most attention. While CO2 has major effects on the Earth’s climate and subsequently our way of life, ozone is one pollutant that does not receive nearly as much attention as it should. The main view that the general public holds regarding ozone is its ability to block harmful sun rays which may cause skin cancer in humans. Although this is true, it mostly applies to ozone in the upper parts of the atmosphere. Ozone levels in the actual air we breathe has many negative effects that very few people know about.

Below is a recorded newscast of how ozone has affected the lives of many:

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Ozone-1,3-dipole by Benjah-bmm27 via Wikimedia Commons

Ozone is an oxidant which has harmful effects on biological life. At the University of British Columbia (UBC), Dr. Steyn, a professor of Earth and Atmospheric Sciences, has recently modeled past ozone trends in the Lower Fraser Valley using various computer simulations. To gain a better understanding of the issue, we interviewed Dr. Steyn about his study and the motivations behind his research. Steyn was interested in comparing past ozone trends with emissions, “to understand which part of the emission reductions have actually had the effect, and then for [policymakers] to use that to build the policy.” More often than not, various governments have rushed plans into action. For example, “Metro Vancouver has made two air quality management plans” that Steyn considers to be made “without  scientific guidance.” Therefore, he “deliberately framed the research in a way that the results could be used for policy…Metro Vancouver has a big process going to understand ozone and what reductions they need to make further.”

Here is a video outlining Dr. Steyn’s study of harmful ozone pollution  and its effects in the Lower Fraser Valley:

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SCIE 300 OUTREACH_SECTION 210_GROUP 2 by kyuuke1013SK

Although we have a clear idea of the present worsening ozone trends, there are still many difficulties, especially emission reductions. Society must strike a balance between the life of convenience that we are accustomed to and the general health of the public. In general Canada manages to  balance things  very well but areas like the Lower Fraser Valley have room for improvement. Our publicly funded healthcare system makes it possible for us to clearly and precisely determine what the cost of degraded air quality is compared to the cost of improving air quality in areas such as Fraser Valley; and we know that the cost of cleanup is a great deal cheaper than the health care costs.

This model is a tool that can be used by researchers and policy makers to increase our understanding of what must be done to ensure the best air quality possible. The health problems that arise from pollutants such as ozone must be avoided at all costs. Progress towards this goal has been made, but there is still much more that needs to be done before we can take a deep sigh of relief!

– Alex Gibson, Stella Meng, Earvin Remandaban, Christine Wong

 

Would you like to sequence your genome?

Imagine a world where you are able to gain access of your entire genome within minutes. Not only will you become aware of what makes you unique, but it will also help with the diagnoses and treatments of many diseases. Thanks to next-generation sequencing technologies like Illumina and 454, we are one step closer to converting this fantasy into a reality.

Next-generation sequencing technology: Illumina. Author: Dr. Corey Nislow, used with permission.

Currently, these new technologies have the ability to sequence five human genomes in one week. This is astonishing because each genome is around 4.3 meters long with over 20,000 genes that code for proteins. Given its efficiency with deciphering human DNA, you would expect high performance on bacterial and archaeal microorganisms that have smaller genomes. By determining their genetic information, it is possible to compare different types of DNA and look back on the evolutionary origin of these life forms.

Check out this podcast to learn more about the evolutionary background of Bacteria, Archaea, and Eukarya:

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A study done by Dr. Nislow and his colleagues has demonstrated the usage of next-generation sequencing, particularly Illumina. They compared the structure and function of chromatin, a DNA- protein complex which contains genetic information, in Archaea and Eukarya by sequencing their genomes. The video below gives a more detailed overview of the research:

YouTube Preview Image Youtube user: stephanieem (SCIE 300 Group 1)

In addition to their rapid sequencing speed, these new technologies have other advantages over the conventional methods. Not only are they highly accurate, but they also provide a larger amount of data for a lower price. For example, when using Illumina, it costs around ten cents to sequence a million nucleotide bases, the fundamental units of DNA. Although this may seem a whole lot, each human cell has over 12 billion bases of DNA!

File:DNA chemical structure.svg

Picture of DNA showing the 4 different nucleotide bases. Author: Madprime via Wikimedia Commons

With the advent of the next-generation sequencing technologies, it is now possible to achieve many tasks that would otherwise remain unresolved. As they continue to become more advanced, many excitements in this field lie ahead. You never know, genome sequencing might even become an application on our computers where we will be able to see for ourselves what makes each one of us so unique.

-Group 1: Daniel (Sanggi) Hong, Stephanie Mrakovich, Maral Altanbadralt, Jing Xiang Yang

Why do we crave?

With the Spring season beginning here in Vancouver, we know that soon enough it will be that time of the year to hit the beach and relax. For most girls and maybe some guys, this time of the year is known as swimsuit season in which the focus is not necessarily laying by the beach but it is on losing that final few pounds to look good in our bathing suits. For some, it is an absolute challenge to be on a diet and it definitely does not get any easier with all the food cravings that arouse in people.

The Monell Chemical Senses Center revealed that although almost anyone can get a food craving, there is a gender difference as 100% of females and 70% of males experienced a food craving in the past year. Also, in Europe and North America, women tend to crave sweets whereas men prefer savory foods; both of which are foods rich in fat and calories making it even more challenging for that diet. A geographical difference is also said to exist as women in Japan are more likely to crave sushi rather than the typical answer of chocolate we get here in Canada.

Resisting the Urge

Results of the most craved item from 1000 Canadian college students
Source: WSJ Reporting

Participants during a study in 2004 were asked to imagine their favorite food while connected to an MRI scanner. From the images, the caudate area of the brain lit up which controls the dopamine activity, a hormone produced during sexual and drug activity, as well as, gambling. Therefore, the pleasure and addictiveness of  these activities and certain food cravings are said to follow similar neural pathways.

So why are all of these foods high in fats and calories being craved? It is because the brain is given feelings of pleasure and euphoria when high amounts of the chemical opioid is released from the foods high in fat and sugar and enters the bloodstream. Researchers have also stated that when a person consumes too much foods high in fat and sugar the dopamine receptors tend to crash and shut itself down leading to fewer working dopamine and more cravings.

On a closing note, to help you reduce those cravings for the swimsuit season, here are a few tips from Jillian Michaels, personal trainer and reality show host of NBC’s  the Biggest Loser.

YouTube Preview Image YouTube account: EverydayHealth

-Maral Altanbadralt

Motion sickness: A quarrel between the eyes and ears

Have you ever started reading your notes or textbook on the bus ride to school, only to find yourself feeling dizzy and nauseous moments after? Or perhaps you’ve experienced the same set of unsettling symptoms on a plane ride, or on a lovely – or in this case, not-so-lovely – Caribbean cruise. Regardless of where you were, it sounds like you were hit by a bad case of motion sickness, a condition that arises due to changes in our sense of balance and equilibrium. As a result, such a phenomenon can develop from the movements of a car or boat, the turbulence of an airplane, or even from the twirls and loops of a ride at an amusement park.

Teacups

If you’re prone to motion sickness, this ride probably isn’t for you.
By jpesci via Flickr Creative Commons

So what causes motion sickness and why do we experience such discomfort as a result? First of all, motion is detected by the brain via signals sent from the inner ear, the eyes, and various sensory receptors throughout the body, and are therefore coordinated together when we walk or move ourselves consciously.

On the other hand, motion sickness occurs when the eyes and ears send different signals to the brain. In this scenario, the movement that is visually perceived “disagrees” with the movement sensed by a specialized system associated with our inner ear. This system, more so known as the vestibular system, contains the organs responsible for the maintenance of proper balance and orientation. Thus, a disturbance to the inner ear caused by any form of repeated motion can cause a person to experience dizziness, fatigue, and nausea, which is explained in this video by YouTube user Alex Dainis.

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This explains why motion sickness can be experienced while reading in a moving vehicle. While your eyes are fixed on an object that is stationary, your body and inner ear sense movement from the speeding or turning vehicle, causing some sort of disagreement between the two.

The vestibular system constitutes the inner ear.
By Rage via Wikimedia Commons

In many cases, motion sickness will ultimately lead to vomiting. This is because the mismatch of signals sent to the brain by the eyes and inner ear suggests that a neurotoxin was ingested, causing the body to induce vomiting in order to get rid of it.

While around 33% of people are prone to motion sickness under mild conditions, 66% experience it under more extreme conditions. Although it is hard to prevent most cases of motion sickness, this video by YouTube user mayoclinic presents some remedies that can be followed to avoid or lessen its effects. If you are one of the 33% that is easily susceptible to this unnerving condition, perhaps these will help make your next vacation or road trip a little more enjoyable.

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– Clarissa Ngui

The Super Supercapacitor.

I’m sure some of you out there have, at one point or another, thought “is the lifestyle we live in the first world sustainable?” The overwhelming scientific consensus is that things need to change if we are going to keep things the way they are now. This is much easier said than done though since we are a society that is heavily dependant on fossil fuels and batteries for energy, and incidentally these are two of the reasons why our environment is changing for the worse.

These problems we are facing opened the door for a potentially world changing discovery. Back in 2010, the nobel prize in physics was awarded to Andre Geim and Konstantin Novoselov for their groundbreaking work with a material called graphene. Since then research into this material has exploded and the potential applications seem boundless.

Graphene by AlexanderAIUS via Wikimedia Commons

Graphene itself is about 100 times stronger than steel; if you were to make a 1 square meter sheet of the material and make it 1000 times thinner than a piece of paper and hang this up like a hammock it would be able to hold up a 10 pound cat, but would weigh less than one of its whiskers. Aside from its possible application of an awesome super light hammock, this material has researchers buzzing about its potential for the technology and energy industries.

Graphene also has the ability to act as a super capacitor, which means that it is able to store large amounts of energy while only taking a fraction of the time to charge compared to batteries. Imagine a cell phone you could charge in a few seconds or an electric car that only takes a few minutes to charge up and not a few hours. This has been the central property of a new discovery made by Dr. Richard Kaner and his colleagues. They found that they could convert liquid graphite oxide into graphene using only a consumer grade DVD drive.

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The Super Supercapacitor by focusforwardfilms

Things like the cell phones or smart screens that can be rolled up, or ultra thin computers could become a reality because of graphene. Think it doesn’t get much better than this? Think again. On top of all the wondrous possibilities graphene could have for cell phones, computers and car batteries, but because this material is purely made out of carbon it is not only bio degradable, it is completely compostable.

I don’t know about all of you but I’m pretty excited for what the future holds now.