Category Archives: Science in the News

Are You Sure You Are Allergic to That?

Imagine you have been allergic to something for most of your life. But now you’re told that it may not be true. Do you trust it? Recent studies show that there is a substantial number of patients incorrectly labelled as having an allergy to penicillin. Some even call this unverified allergy an epidemic. An estimated 32 million people in the United States are documented to be allergic to penicillin. That would mean that 1 out of 10 people reading this are allergic. Yet, over 90% of these patients are not actually allergic to penicillin.

Penicillin is one of the oldest antibiotics for bacterial infections. Alternatives to this drug raise concerns as they are less effective, more expensive and sometimes more toxic. Therefore, doctors only choose to prescribe alternatives when options are limited.

Penicillin is often termed the wonder drug for it’s ability to fight infections. Source: Flickr Commons

If a patient is labelled with an allergy to penicillin, doctors, with good reason, choose to err on the side of caution and prescribe an alternative medication to fight the infection. A misdiagnosis may occur when symptoms are thought to appear when penicillin was taken, i.e. when penicillin is prescribed to a sick child. If a viral infection is mistaken for a bacterial one then the symptom that is developed from the virus may be attributed to the drug instead. Thus incorrectly concluding the child is allergic.

A skin test is the definitive tool to determine if an allergy exists. The procedure involves pricking the skin and  observing the reaction. Doctors can then determine if the patient is actually allergic to the drug in question.

Allergy skin test. See how allergies are identified by the appearance of red and inflamed areas. Source: Wikimedia Commons

A study published in 2017 created an approach for testing and challenging the penicillin allergy label. Patients who were admitted to the hospital underwent an investigation of their allergy history with a pharmacist. Then, if appropriate, the patient would undergo a penicillin skin test. If the test was negative, the allergy would be challenged and the patient would be given a penicillin-like drug. Results showed that one-third of the patients were switched to penicillin successfully leading to less days spent in the hospital and lower hospital bills.

Another paper developed a similar way to evaluate reported penicillin allergies. First, the history of the allergy is researched to determine the risk. Those with mild symptoms would be low-risk while those that develop breathing problems would be moderate to high-risk. Low-risk patients would be given a course of a penicillin-like drug and observed for symptoms of a reaction. Moderate-risk patients would first undergo a penicillin skin test and then given a round of the drug if the skin test was negative. High-risk patients were not challenged and referred to a specialist. Those who tolerated the drug administration then had the allergy removed from their health records.

Both papers emphasize the necessity that penicillin allergy testing  become part of the admission process to a hospital. This test saves money and reduces the chance for patients to get further infections from less effective drugs. Plans for allocating funds in hospitals may need to incorporate this information to better treat patients in the future. 

  • Katie Donohoe

Is it Me or is the Sea Rising?

Sea level rise – the consequence of climate change that is creating fear in societies across the globe, especially those in low-lying coastal areas. Sadly, climate scientists have not been able to quantify how much the sea will rise. Why? It depends on where you live.

Regional Factors

Rebound or Subsidence?

Believe it or not, land can rise (rebound) or fall (subsidence). For instance, Canada is rebounding as it was compressed under the weight of glaciers during the last ice age. In contrast, land masses such as South England are experiencing subsidence as these non-glaciated areas had been elevated by glaciers in the periphery. A modern forcing to land subsidence is the exploration for natural resources like oil and gas. Resources are found in subsurface deposits, but once these units are drained of their contents, the subsurface material will collapse from the weight above. Clearly, the glacial history and economy of your region do have an impact in whether you are moving towards or away from sea level. 

Glacier Rebound and Subsidence (blogger). Credit: Tom James, Natural Resources Canada. Link: http://www.antarcticglaciers.org/glaciers-and-climate/sea-level-rise-2/recovering-from-an-ice-age/

Gravitational Effects

The gravitational force, the same pull that keeps you planted on Earth, can have an impact on sea level rise. Gravity is defined as an attractive force between two bodies of mass. The interactions of most importance exist between seawater and the Greenland & West Antarctic ice sheets. Enormous in size (large mass), these sheets exert a very strong pull on seawater. It is so strong that water is pulled from regions thousands of kilometres away. As mass is lost during melting, the pull is weakened, and water freely flows away. Depending on your region’s relative location and the glacier’s size, some areas are expected to experience a greater sea level rise than others. For example, due to the strong pull by the Antarctic ice sheet, northern areas have lower sea levels compared to those in the southern hemisphere. Unfortunately, these distant areas will experience a relatively larger change in sea level as water is released from the pull of this ice sheet.

The gravitational effect of an ice sheet on sea level
(blogger). Credit: Jerry Mitrovica & Natalya Gomez, University of Toronto. Link: https://www.sciencedaily.com/releases/2009/02/090205142132.htm

Changing Ocean Currents

Ocean currents are changing with our warming climate and a region’s proximity to an overturn zone can influence the local change in sea level. For example, the United Kingdom is near an overturn zone (of the Gulf Stream) where warm water from the equator cools and sinks. However, it is becoming increasingly difficult for this water to sink as its density has decreased due to a warmer northern climate and dilution from the melting of the Greenland ice sheet. This results in more water at the surface, or in other words, an elevated sea level.

Ocean overturn (blogger). Credit: World Ocean Review. Link: https://worldoceanreview.com/en/wor-1/climate-system/great-ocean-currents/

 

In short, regional variations make it challenging for climate scientists to quantify sea level rise. However, there are many more factors that I have not shared with you, such as the complexity behind ice sheet dynamics, which further complicate this task.

Interested in the effects of sea level rise on Metro Vancouver and/or how governments are responding? Check out the video below!

Credit: Government of British Columbia

-Malavan Subramaniam

 

First plant to grow on the Moon ever!

Do you think we can one day sustain life outside of Earth? Perhaps one day in the future, but when will that be? That day may be sooner than you think!

The first time biological matter to  sprout and grow on the moon has been achieved! On January 2nd 2019, China’s Chang’e-4 lunar probe landed on the far side of the moon where no human or robot has ever ventured before.  It carried a “lunar biosphere” experiment containing plant seeds and silkworm eggs.  The plan is that the plants provide oxygen for the silkworms, and in turn, the silkworms will nurture the plants with its waste and released carbon dioxide. There are potato, rock-cress and cotton seeds among the seeds carried on board.  The “biosphere” experiment is all contained inside a 0.8 liter aluminum alloy cylinder weighing in around three kilograms and includes nutrients, water and dirt.  Sunlight is filtered into the container through a tube with small cameras set up inside. The cameras watch the environment and relay the footage back to Earth through a complicated relay system. The accomplishments so far show great progress towards sustaining life on the moon.

A picture of Yutu-2 taken by the Chang’e-4 lunar probe. Source: China National Space Administration (CNSA)

The Far Side of the Moon

The moon’s rotation speed is in sync with Earth’s orbit.  This results in the moon rotating on its axis and also orbiting the Earth every 28 days.  The same face of the moon always faces Earth, and the side we can’t see from the planet’s surface is considered the far side.

source: YouTube
Why is it hard to land on the far side of the moon?

To put it bluntly, the moon blocks radio contact to Earth and makes it very difficult to maintain a communication link. To overcome this issue, in May 2018, CNSA launched a satellite Queqiao into orbit around “L2.” L2 is a point beyond the moon where the gravity of the moon and Earth cancel out the centripetal force of an object stationed there. This satellite helps bridge the gap between the Chang”e-4’s lander and mission control.

China has sprouted plants on the moon!

A picture taken on January 12th 2019 of the cotton seeds growing after the excitement of them sprouting a few days prior. Source: Chongqing University.

Out of all the germinated seeds (rapeseed, potato seed, cotton seeds), the cotton seeds were the first to sprout.  This amazing breakthrough could be the start to a new era and displays great progress towards a system where food ( such as potatoes), clothing (from the cotton), and oil (from rapeseed) can be sustained for space explorers.  Being able to grow plants on any celestial body outside of Earth will be necessary for any future human settlements outside of Earth.

In the future, if things go as planned, China will launch Chang’e-5 sample-return mission later this year. Let’s all look forward to the future progress together! Keep an eye out!

-Peter Le

If Focusing Was Just This Easy

We’ve all been there: either we’ve procrastinated by leaving all of our studying to the last day or, we’ve forgotten to do a paper until the night before. This is often where study drugs are introduced.

The Basic Facts

Adderall is a study drug, also known as a smart drug that is often prescribed to individuals with Attention Deficit Hyperactivity Disorder (ADHD). However, like many other prescription drugs, people have been using Adderall for purposes such as recreation and studying. As reported by the National Survey on Drug Use and Health, roughly 6.4 percent of college students have been found to use Adderall for recreational purposes. Particularly, most students think that Adderall will strengthen their ability to study. Although an Adderall prescription must be obtained from a doctor, people still have access to this drug from other sources.  A 2016 Recovery Brands survey showed more than 60% of individuals aged 18-28 get their hands on doctor-prescribed Adderall through family, classmates and street dealers.

How It Works

This drug works by increasing the amount of dopamine and norepinephrine in a user’s brain. Dopamine, also known as the pleasure centre of the brain, is responsible for our fight-or-flight response which controls focus, clarity and alertness. Norepinephrine helps to make all of these behaviours last longer. Combined, these two neurotransmitters allow the user to stay more focused, be more alert, pull all-nighters and be more efficient while studying.

The Big Picture

Nonetheless, the side effects of taking Adderall can be very detrimental to users. Some symptoms include irregular heartbeats, high blood pressure, nausea and loss of appetite. There has been a recent study showing correlation between this study drug and long term memory loss. Additionally, just like with any other drug, there is potential to become addicted to Adderall. According to the Drug Enforcement Administration’s Schedule II list of substances, Adderall is classified as a drug with a high potential for abuse that can lead to physical and psychological dependence.

Overall, study drugs may help you stay awake in order to cram information before an exam, but are the “benefits” worth the negative effects? Definitely no.

Basima Spindari

Genetic Genealogy: Using DNA for Police Investigations

Catching Culprits

The Golden State Killer terrorized California from 1974 to 1986. He killed at least 13 people and committed a series of rapes and burglaries during this twelve-year period, but was never caught. On April 24, 2018 however, Sacramento County Sheriff’s Department arrested Joseph James DeAngelo, who they believed was responsible for the crimes, before formally charging him. Genetic Genealogy was responsible for bringing him to justice and now crime solvers believe that more cold cases can be solved with this exciting method. While DNA profiling has been around since 1984, the genetic database was not large enough at the time to be as effective as it is today.  How it works is that genealogists upload DNA sequences from a crime scene to a large database consisting of genetic profiles from a mass of other individuals in order to find the relatives of an unknown suspect. Afterward, they narrow in on the possible perpetrator by constructing a family tree and pass on the information to law enforcement.

A Family Tree. Image from:                                            https://www.wikihow.com/Design-a-Family-Tree#/Image:Design-a-Family-Tree-Step-19.jpg

 

But First… what are SNPs?

Single Nucleotide Polymorphism (or SNPs) are markers in our entire DNA set. They signify that a portion of individuals will have one building block, called a nucleotide, at a specific position in a nucleotide sequence, but other people will have a different nucleotide (four different types) at that same position.  The two forms of SNPs are known as alleles.

https://digitalworldbiology.com/citation

This segment of a DNA strand has one SNP that does not match. Image from Molecule World: https://digitalworldbiology.com/archive/genetic-variation-i-what-snp

 

The Process

So how do genealogical DNA tests work? There are actually three major types of tests that can be conducted. Our focus is on the autosomal DNA test, which targets chromosomes 1-22 for analysis (the non-sexual somatic chromosomes). This testing method allows individuals to be matched within a database. An individual being tested may have a number of consecutive SNPs in common with a person already in a system’s database, in which case it can be inferred that they share a DNA segment within that section of their genomes. If this segment is longer than a threshold value set by a certain group, then the two subjects are treated as a match. Since half of the genetic information is inherited from each parent, the SNP of each individual decreases by approximately half each generation, but genealogical DNA tests generally account for about 700,000 SNPs. With this in mind, it is not expected that even somewhat distant family members will fail to match (as was the case in DeAngelo’s situation).

Video about how DeAngelo was caught. Video from CBC News: The National.

 

The Limitations

While this method is very effective, it does pose some limitations as well. DNA that is contaminated, degraded, or too small in amount can leave room for doubt when attempting to make a match. Also, due to privacy issues, many DNA-testing firms will not provide law enforcement any access to their database without consent from the user of the data or by a court order.

Genetic Genealogy is an effective way of solving cold and even active criminal cases. While some restrictions exist, the vast database now available can be a great resource for law enforcement.

– Hani Ghaffari

Is Taking Popular Supplements a Waste of Money?

How many dietary supplements do you take every day? According to Statistics Canada, about half of the Canadians take at least one supplement a day.  There are so many supplement products in the market today and consumers are overwhelmed with all the choices available. Are these supplements really necessary for maintaining good health? A recent review article published in the Journal of American College of Cardiology suggests otherwise.

How Supplements are made

Most supplements are synthetically made in laboratories and very few are made from naturally derived ingredients. In terms of chemistry, there is no difference found between the synthetically derived and naturally derived supplements. Most of the commercial vitamins found are made synthetically due to cost and efficiency.

Wide selection of vitamin supplements found in drugstores (source: Wikipedia)

Research on popular supplements

A team of researchers from St Michael’s Hospital and the University of Toronto claims that taking vitamin and mineral supplements have no significant effect on one’s health. The team reviewed 179 studies with single randomized trials that were published from January 2012 to October 2017. According to their review, the most common supplements taken were multivitamins, vitamin D, calcium and vitamin C. Their findings on these four common supplements reveal that there is little to no evidence in preventing cardiovascular diseases or early death. However, among all the dietary supplements that were reviewed, vitamin B9 (folic acid), and other B-vitamins such as B6 and B12 with folic acid were found to decrease the risk of stroke by 20%. On the other hand, the team was able to conclude that vitamin B3 (niacin) and antioxidants have rather a negative effect on our body, which may even lead to early death regardless of the cause.

What should we do?

Dr. David Jenkins, the lead author of the study reassures people that there is no harm in taking most of the popular supplements, however, he also adds that people should know that there are no significant benefits in taking them. He recommends that people should rely on eating a healthy and balanced diet to get their vitamins and minerals. According to his research, fruits, nuts, and whole wheat pasta were some of the foods that people should consider adding to their grocery list.

Here is a video from TED-Ed providing background information on the vitamins that were mentioned in the review. (Source: YouTube)

Tina Kwon